Evidence map›Paper›PMID 40267294›Full record

ArticleJournal of Alzheimer's disease : JAD2025

Generation of human induced pluripotent stem cell-derived cortical neurons expressing the six tau isoforms.

Houbo Jiang, Zichun Xiao, Komal Saleem, Ping Zhong, Li Li, Gaurav Chhetri, Pei Li, Zhongjiao Jiang, Zhen Yan, Jian Feng

Abstract read
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Houbo JiangDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0009-0005-0564-0263
Zichun XiaoDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0009-0000-0475-9442
Komal SaleemDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0000-0002-5955-4935
Ping ZhongDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0000-0002-8891-344X
Li LiDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0000-0002-7404-3658
Gaurav ChhetriDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0000-0002-0893-7848
Pei LiDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0000-0001-5509-7848
Zhongjiao JiangDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0000-0003-1465-0090
Zhen YanDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0000-0002-3519-9596
Jian FengDepartment of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0000-0001-7630-8800

Funding

Transcriptomic and Circuitry Aberrations in Alzheimer’s DiseaseR01AG079797 · NIA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI JIAN FENG, Zhen Yan · 2023 to 2026
$3.0M
Molecular Segregation of Parkinson’s Disease by Patient-Derived NeuronsR01NS113763 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI FENG, JIAN · 2020 to 2024
$2.6M
Targeting Histone K4 Methylation for Treatment of Alzheimer's Disease and Related DementiaR01AG064656 · NIA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI YAN, ZHEN · 2019 to 2023
$2.5M
Epigenetics-Based Autism Treatment with Animal Models and Human Stem CellsR01NS127728 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI JIAN FENG, Zhen Yan · 2023 to 2026
$2.5M
New Treatment Strategy for Alzheimer’s DiseaseR21AG067597 · NIA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI FENG, JIAN, YAN, ZHEN · 2020 to 2021
$439k
NIA NIH HHS R01 AG064656NIA NIH HHS R01 AG079797NIA NIH HHS R21 AG067597NINDS NIH HHS R01 NS113763NINDS NIH HHS R01 NS127728
6 · The paper itself

Abstract

BackgroundThe alternative splicing (AS) of

Indexed as

Cell DifferentiationCerebral CortexInduced Pluripotent Stem CellsNeuronstau ProteinsCells, CulturedHumansProtein IsoformsMAPT protein, humanProtein Isoformstau Proteinsalternative splicingAlzheimer's diseasecortical neuronscyclopamineinduced pluripotent stem cellsMAPTtautauopathiesXAV939

Identifiers

PMID40267294
PMCPMC12754833

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.