Evidence mapPaperPMID 40267911Full record

ReviewNeuron2025

Integrating endocannabinoid signaling, CCK interneurons, and hippocampal circuit dynamics in behaving animals.

Shreya Malhotra, Florian Donneger, Jordan S Farrell, Barna Dudok, Attila Losonczy, Ivan Soltesz

Abstract readReview
In one paragraph

Review in Neuron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  6. bioRxiv : the preprint server for biology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shreya MalhotraDepartment of Neurosurgery, Stanford University, Stanford, CA, USA. Electronic address: shreyama@stanford.edu.
Florian DonnegerDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Jordan S FarrellDepartment of Neurology, Harvard Medical School, Boston, MA, USA; Rosamund Stone Zander Translational Neuroscience Center, Boston Children's Hospital, Boston, MA, USA; F.M. Kirby Neurobiology Center, Harvard Medical School, Boston, MA, USA.
Barna DudokDepartment of Neurology, Baylor College of Medicine, Houston, TX, USA.
Attila LosonczyDepartment of Neuroscience, Columbia University, New York, NY, USA; Kavli Institute for Brain Sciences, Columbia University, New York, NY, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
Ivan SolteszDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.

Funding

Experimental and modeling investigations into microcircuit, cellular and subcellular determinants of hippocampal ensemble recruitment to contextual representationsR01MH124867 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2022 to 2025
$2.7M
Local Circuit Control of Rapid Plasticity and Tunable Ensemble Formation in the HippocampusRF1NS133381 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Attila Losonczy, IVAN SOLTESZ · 2023 to 2023
$2.6M
Control of Axon Initial Segment in EpilepsyR01NS121106 · STANFORD UNIVERSITY · 2025 to 2025
$635k
Activity-dependent endocannabinoid control in epilepsyR01NS131728 · STANFORD UNIVERSITY · 2025 to 2025
$585k
Dissecting Hypothalamic Pathways for Seizure ControlR00NS126725 · BOSTON CHILDREN'S HOSPITAL · 2025 to 2025
$249k
Perisomatic inhibition in epilepsyR00NS117795 · BAYLOR COLLEGE OF MEDICINE · 2025 to 2025
$224k
NIA NIH HHS RF1 AG080818NIMH NIH HHS R01 MH124047NIMH NIH HHS R01 MH124867NINDS NIH HHS R00 NS117795NINDS NIH HHS R00 NS126725NINDS NIH HHS R01 NS121106NINDS NIH HHS R01 NS131728NINDS NIH HHS RF1 NS133381
6 · The paper itself

Abstract

The brain's endocannabinoid signaling system modulates a diverse range of physiological phenomena and is also involved in various psychiatric and neurological disorders. The basic components of the molecular machinery underlying endocannabinoid-mediated synaptic signaling have been known for decades. However, limitations associated with the short-lived nature of endocannabinoid lipid signals had made it challenging to determine the spatiotemporal specificity and dynamics of endocannabinoid signaling in vivo. Here, we discuss how novel technologies have recently enabled unprecedented insights into endocannabinoid signaling taking place at specific synapses in behaving animals. In this review, we primarily focus on cannabinoid-sensitive inhibition in the hippocampus in relation to place cell properties to illustrate the potential of these novel methodologies. In addition, we highlight implications of these approaches and insights for the unraveling of cannabinoid regulation of synapses in vivo in other brain circuits in both health and disease.

Indexed as

Behavior, AnimalCholecystokininEndocannabinoidsHippocampusInterneuronsNerve NetSignal TransductionAnimalsCholecystokininEndocannabinoidsbehaviorbrain stateCB1 receptorcholecystokinindiseaseendocannabinoidhippocampusinhibitioninterneurontranslational

Identifiers

PMID40267911
PMCPMC12410895

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.