Evidence map›Paper›PMID 40267913›Full record

ArticleCell metabolism2025

Circulating glycerate predicts resilience to fructose-induced hepatic steatosis.

Cuauhtemoc B Ramirez, In Sook Ahn, Varvara I Rubtsova, Ingrid Cely, Johnny Le, Joohwan Kim, Sunhee Jung, Miranda E Kelly, Yeojin Kim, Hosung Bae and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Cuauhtemoc B RamirezDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA; Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA, USA.
In Sook AhnDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Varvara I RubtsovaDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA; Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA, USA.
Ingrid CelyDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Johnny LeDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Joohwan KimDepartment of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA, USA.
Sunhee JungDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Miranda E KellyDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Yeojin KimDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Hosung BaeDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Won-Suk SongDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Yasmine H AlamDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Guanglin ZhangDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Graciel DiamanteDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Alina ChaoDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Lauren HoffnerDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA; Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA, USA.
Alexis AnicaDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA; Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA, USA.
Izabelle LeDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA; Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA, USA.
Miranda L LopezDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Ian J TamburiniDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Elena M MoyerDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Ariel TsaiDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Qin YangDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
Xing DaiDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Daniele PiomelliDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA; Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA, USA; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, USA.
Gina LeeDepartment of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA, USA; Center for Epigenetics and Metabolism, University of California, Irvine, Irvine, CA, USA. Electronic address: ginalee85@gmail.com.
Xia YangDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: xyang123@ucla.edu.
Cholsoon JangDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA, USA; Center for Epigenetics and Metabolism, University of California, Irvine, Irvine, CA, USA. Electronic address: choljang@uci.edu.

Funding

CARCINOGENESIST32CA009054 · UNIVERSITY OF CALIFORNIA-IRVINE · 1985 to 2025
$2.9M
Systems Genetics Dissection of Non-alcoholic SteatohepatitisR01DK117850 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2025 to 2025
$654k
Elucidating dietary fructose and alcohol interactions during liver cancer developmentR01AA029124 · UNIVERSITY OF CALIFORNIA-IRVINE · 2025 to 2025
$439k
Intrinsic and extrinsic control of epithelial tissue stem cell activityR35GM145307 · UNIVERSITY OF CALIFORNIA-IRVINE · 2025 to 2025
$432k
Elucidating the regulation of RNA methylation by mTOR signaling in cancerK22CA234399 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Gina Lee · 2022 to 2022
$182k
Elucidating the role of nonessential amino acid metabolism in diabetic skin woundsF31DK134173 · UNIVERSITY OF CALIFORNIA-IRVINE · 2025 to 2025
$55k
NCI NIH HHS K22 CA234399NCI NIH HHS T32 CA009054NIAAA NIH HHS R01 AA029124NIAAA NIH HHS R21 AA030358NIDDK NIH HHS F31 DK134173NIDDK NIH HHS R01 DK104363NIDDK NIH HHS R01 DK117850NIGMS NIH HHS R35 GM145307
6 · The paper itself

Abstract

Excessive intake of dietary fructose increases the risk of metabolic-dysfunction-associated steatotic liver disease (MASLD), cirrhosis, and cancers. However, what host factors determine disease vulnerability is incompletely understood. Here, we leverage genetically divergent mouse strains, mass spectrometry-based metabolomics, and in vivo isotope tracing, identifying circulating glycerate as a biomarker that predicts resilience to fructose-induced hepatic steatosis in both sexes. We found that the surge of circulating glycerate after an oral fructose provision reflects strong small-intestinal fructose catabolism. Such fructose clearance by the small intestine is linked to a weaker induction of hepatic de novo lipogenesis and steatosis upon chronic fructose exposure across strains. These data indicate the potential utility of an oral fructose tolerance test and circulating glycerate measurements to predict an individual's susceptibility to fructose-elicited steatotic liver and provide personalized dietary recommendations.

Indexed as

Fatty LiverFructoseAnimalsBiomarkersFemaleLipogenesisLiverMaleMiceMice, Inbred C57BLNon-alcoholic Fatty Liver DiseaseBiomarkersFructosefructosein vivo isotope tracingliquid chromatography spectrometryMASLD

Identifiers

PMID40267913
PMCPMC12058382

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.