ArticleNature2025
Geographic and age variations in mutational processes in colorectal cancer.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
104 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Unveiling the immune microenvironment in sinonasal intestinal type adenocarcinoma: new arguments for immunotherapy.Oncoimmunology · 2026Article
- Gut microbiota and diet in colorectal cancer: Converging determinants of carcinogenesis.Gut microbes · 2026Review
- Rising Incidence and Mortality of Colorectal Cancer Among Younger Adults: A Population-Based Study in Taiwan, 1994-2018.International journal of cancer · 2026Article
- Early microbial encounters, lasting effects: strains matter.Nature reviews. Microbiology · 2026Article
- Shaping the future of early-onset colorectal cancer prevention.Nature reviews. Cancer · 2026Review
- Early-Onset Colorectal Cancer: Clinical and Molecular Features with Emerging Insights from Comprehensive Genomic Profiling.Oncology and therapy · 2026Review
- Dietary Fructose and Early-Onset Colorectal Cancer: Metabolic, Microbial, and Translational Perspectives.Microorganisms · 2026Review
- Integration of multi-omics data uncovers novel germline susceptibility candidates in early-onset colorectal cancer.European journal of human genetics : EJHG · 2026Article
- Prevalence and chronology of colibactin-associated mutational processes and their microbiome spectra in Japanese colorectal cancer.Nature genetics · 2026Article
- Article
- Quantitative MRI T1 relaxation time as a biomarker of complete response in rectal cancer six weeks after neoadjuvant therapy: a prospective study.Clinical and translational radiation oncology · 2026Article
- The Landscape of Genomic and Socioeconomic Variables in Patients with Colorectal Cancer Based on Genetic Ancestry.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Age-stratified mutation patterns in early-onset colorectal cancer reveal distinct molecular features and therapeutic implications.ESMO gastrointestinal oncology · 2026Article
- Early-Onset Colorectal Cancer: From Epidemiologic Shift to Life-Course Carcinogenesis and Age-Attuned Care.Current oncology reports · 2026Review
- Centralized processing of frozen tumor tissues for global cancer genomics.Nature protocols · 2026Review
- Identification and validation of a previously missed mutational signature in colorectal cancer.Nature communications · 2026Article
- Gut Microbiome-Driven Strategies to Overcome Immunotherapy Resistance in Microsatellite-Stable Colorectal Cancer.Cancers · 2026Review
- Cancer Mortality Before Age 50 Years.JAMA network open · 2026Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
63 authors.
Marcos Díaz-Gay *Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-0658-0467
Wellington Dos Santos *Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Sarah Moody *Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0003-4904-1041
Mariya KazachkovaDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Ammal AbbasiDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Christopher D SteeleDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Raviteja VangaraDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-5272-6207
Sergey SenkinGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.ORCID http://orcid.org/0000-0001-5848-005X
Jingwei WangCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-0201-2369
Stephen FitzgeraldCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0003-0585-4833
Erik N BergstromDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Azhar KhandekarDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Burçak OtluDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Behnoush Abedi-ArdekaniGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Ana Carolina de CarvalhoGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Thomas CattiauxGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.ORCID http://orcid.org/0000-0002-4826-7965
Ricardo Cortez Cardoso PenhaGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Valérie GaborieauGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Priscilia ChopardGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Christine CarreiraEvidence Synthesis and Classification Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Saamin CheemaCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-5297-2042
Calli LatimerCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.
Jon W TeagueCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.
Anush MukeriyaClinical Epidemiology, N. N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia.
David ZaridzeClinical Epidemiology, N. N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia.
Riley CoxOntario Tumour Bank, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
Monique AlbertOntario Tumour Bank, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
Larry PhouthavongsyOntario Tumour Bank, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
Steven GallingerLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-6998-9414
Reza MalekzadehDigestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Ahmadreza NiavaraniDigestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0000-0001-7773-6778
Marko MiladinovClinic for Digestive Surgery-First Surgical Clinic, University Clinical Centre of Serbia, Belgrade, Serbia.
Katarina ErićDepartment of Pathology, University Clinical Centre of Serbia, Belgrade, Serbia.
Sasa MilosavljevicInternational Organization for Cancer Prevention and Research, Belgrade, Serbia.
Suleeporn SangrajrangNational Cancer Institute, Bangkok, Thailand.
Maria Paula CuradoDepartment of Epidemiology, A. C. Camargo Cancer Center, Sao Paulo, Brazil.
Samuel AguiarColon Cancer Reference Center, A. C. Camargo Cancer Center, Sao Paulo, Brazil.
Rui Manuel ReisMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.ORCID http://orcid.org/0000-0002-9639-7940
Monise Tadin ReisDepartment of Pathology, Barretos Cancer Hospital, Barretos, Brazil.
Luis Gustavo RomagnoloDepartment of Colorectal Oncology Surgery, Barretos Cancer Hospital, Barretos, Brazil.
Denise Peixoto GuimarãesDepartment of Endoscopy, Barretos Cancer Hospital, Barretos, Brazil.
Ivana HolcatovaDepartment of Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.ORCID http://orcid.org/0000-0002-1366-0337
Jaroslav KalvachSurgery Department, 2nd Faculty of Medicine, Charles University and Central Military Hospital, Prague, Czech Republic.
Carlos Alberto VaccaroInstituto de Medicina Traslacional e Ingeniería Biomédica (IMTIB)-CONICET-Universidad Hospital Italiano de Buenos Aires (UHIBA) y Hospital Italiano de Buenos Aires (HIBA), Buenos Aires, Argentina.
Tamara Alejandra PiñeroInstituto de Medicina Traslacional e Ingeniería Biomédica (IMTIB)-CONICET-Universidad Hospital Italiano de Buenos Aires (UHIBA) y Hospital Italiano de Buenos Aires (HIBA), Buenos Aires, Argentina.
Beata ŚwiątkowskaDepartment of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Poland.ORCID http://orcid.org/0000-0003-3757-3868
Jolanta LissowskaThe Maria Sklodowska-Cure National Research Institute of Oncology, Warsaw, Poland.
Katarzyna Roszkowska-PurskaDepartment of Pathology, The Maria Sklodowska-Cure National Research Institute of Oncology, Warsaw, Poland.
Antonio Huertas-SalgadoOncological Pathology Group, Terry Fox National Tumor Bank (Banco Nacional de Tumores Terry Fox), National Cancer Institute, Bogotá, Colombia.
Tatsuhiro ShibataLaboratory of Molecular Medicine, The Institute of Medical Science, The University of Tokyo, Minato-ku, Japan.ORCID http://orcid.org/0000-0002-0477-210X
Satoshi ShibaDivision of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Japan.ORCID http://orcid.org/0000-0001-5159-5719
Surasak SangkhathatTranslational Medicine Research Center, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.ORCID http://orcid.org/0000-0003-3622-3233
Taned ChitapanaruxDepartment of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Gholamreza RoshandelGolestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran.ORCID http://orcid.org/0000-0002-5494-0722
Patricia Ashton-ProllaDepartment of Genetics, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Daniel C DaminDepartment of Surgery, Division of Colorectal Surgery, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil.
Francine Hehn de OliveiraDepartment of Pathology, Anatomic Pathology, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil.
Laura HumphreysCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.
Trevor D LawleyParasites and Microbes, Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-4805-621X
Sandra PerdomoGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.ORCID http://orcid.org/0000-0001-7740-8141
Michael R StrattonCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0001-6035-153X
Paul BrennanGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Ludmil B AlexandrovDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA. L2alexandrov@health.ucsd.edu.ORCID http://orcid.org/0000-0003-3596-4515
Funding
Data sharing: the Colon Cancer Family Registry CohortU01CA167551 · NCI · UNIVERSITY OF MELBOURNE · PI Daniel David BUCHANAN, Steven Gallinger · 2018 to 2026
$16.8MDetecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer PreventionR01ES032547 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALEXANDROV, LUDMIL B · 2021 to 2025
$3.4MMapping immuno-genomic drivers of the head and neck precancer invasive-disease transitionU01CA290479 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Jorge Silvio Gutkind · 2023 to 2026
$3.1MComprehensive identification of germline-somatic interactionsR01CA269919 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Hannah Kathryn Carter · 2022 to 2026
$2.2MNCI NIH HHS R01 CA269919NCI NIH HHS U01 CA167551NCI NIH HHS U01 CA290479NIEHS NIH HHS R01 ES032547Wellcome TrustWorld Health Organization 001
Abstract
Incidence rates of colorectal cancer vary geographically and have changed over time
Indexed as
Colorectal NeoplasmsMutationAdultAgedAge FactorsAge of OnsetArgentinaBrazilColombiaFemaleHumansIncidenceINDEL MutationMaleMicrosatellite InstabilityMiddle AgedcolibactinMutagensPeptidesPolyketides
Identifiers
What Socratic holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.