ArticleActa parasitologica2025
In vitro Evaluation of the Nematicidal Efficacy of Quercetin on Adult Toxocara canis.
Article in Acta parasitologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- In vitro evaluation of the anthelmintic activity of citrus flavonoids against free-living and parasitic nematodes.Scientific reports · 2025Article
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2 authors.
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Abstract
purposeToxocara canis is a globally distributed zoonotic parasite found in dogs' intestines, leading to various pathological damages, particularly to the intestinal flora. The larval stage causes human toxocariasis, especially in children, and may result in neurological disorders and blindness. Quercetin is a flavonoid with strong secondary metabolites and possesses medicinal advantages and antiparasitic qualities.
methodsThe assay involved four groups, each of 10 young adult T. canis; Group I was incubated in concentrations of an ethanolic extract of quercetin, Group II in albendazole (0.2 mM/ml) (+ve control), Group III in RPMI 1640 medium with ethanol (control), and Group IV in RPMI 1640 medium only (-ve control). The potential action of quercetin against adult T. canis in vitro was detected using scanning electron microscopy, histological investigations, and enzyme analysis.
resultsSEM declared that exposure to LC90 of quercetin caused body shrinkage, cuticle and caudal papillae swelling, and disfigurement and erosion of cuticular annulations. Compared to albendazole's effect on the treated worm's body wall, results showed that quercetin generates oxidative stress and has an extensive and variable effect on T. canis organs, including the body wall, the gut, and the genitalia.
conclusionQuercetin may set the stage for a new class of medications with remarkable potential for treating parasitic nematodes in dogs and could be extended to humans. This is the first time to employ a comprehensive study illuminating the potential action of quercetin against adult Toxocara canis in vitro.
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