Evidence map›Paper›PMID 40268899›Full record

ArticleCell death discovery2025

Pkd2l1 deletion inhibits the neurogenesis of cerebrospinal fluid-contacting neurons and impedes spinal cord injury repair.

Yi Zhang, Liang Cao, Haijian Yan, Zhangrong Luo, Chanjuan Chen, Zeyu Shangguan, Qizhe Li, Xuexing Shi, Leiluo Yang, Wei Tan and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yi Zhang *Emergency Department, Emergency Medicine Laboratory, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Liang Cao *Emergency Department, Emergency Medicine Laboratory, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.ORCID http://orcid.org/0009-0000-7650-7471
Haijian YanEmergency Department, Emergency Medicine Laboratory, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Zhangrong LuoEmergency Department, Emergency Medicine Laboratory, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Chanjuan ChenEmergency Department, Emergency Medicine Laboratory, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Zeyu ShangguanEmergency Department, Emergency Medicine Laboratory, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Qizhe LiEmergency Department, Emergency Medicine Laboratory, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Xuexing ShiEmergency Department, Emergency Medicine Laboratory, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Leiluo YangEmergency Department, Emergency Medicine Laboratory, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Wei TanEmergency Department, Emergency Medicine Laboratory, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Shengxin YangEmergency Department, Emergency Medicine Laboratory, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Jiangquan FuEmergency Department, Emergency Medicine Laboratory, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Chunqing WangEmergency Department, Emergency Medicine Laboratory, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Xiaowei DouClinical Research Center, Affiliated Hospital of Guizhou Medical University, Guiyang, China. douxw@gmc.edu.cn.ORCID http://orcid.org/0000-0002-9601-7047
Qing LiEmergency Department, Emergency Medicine Laboratory, The Affiliated Hospital of Guizhou Medical University, Guiyang, China. liq168@gmc.edu.cn.ORCID http://orcid.org/0000-0002-2338-150X

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82160249, 81960234
6 · The paper itself

Abstract

Adult neural stem cells (NSCs) offer a promising avenue for restoring spinal cord injury (SCI). However, their precise identity in the mammalian spinal cord remains unclear. Our previous research demonstrated that Pkd2l1-positive cerebrospinal fluid-contacting neurons (CSF-cNs) possess the NSC properties. Furthermore, understanding the role and molecular mechanisms of CSF-cNs as endogenous NSCs in spinal cord repair is crucial for developing effective treatments. This study utilizes a Pkd2l1

Identifiers

PMID40268899
PMCPMC12019451

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.