Evidence map›Paper›PMID 40270550›Full record

ArticleBioactive materials2025

A double network composite hydrogel with enhanced transdermal delivery by ultrasound for endometrial injury repair and fertility recovery.

Xin Zhang, Shufang Wang, Siyu Wang, Zeyi Long, Cong Lu, Jianlin Wang, Lijun Yang, Cancan Yao, Bin He, Xihua Chen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xin ZhangChinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.
Shufang WangDepartment of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, 453003, China.
Siyu WangChinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.
Zeyi LongChinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.
Cong LuNHC Key Laboratory of Reproductive Health Engineering Technology Research, Department of Reproduction and Physiology, National Research Institute for Family Planning, Beijing, 100081, China.
Jianlin WangChinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.
Lijun YangChinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.
Cancan YaoChinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.
Bin HeNHC Key Laboratory of Reproductive Health Engineering Technology Research, Department of Reproduction and Physiology, National Research Institute for Family Planning, Beijing, 100081, China.
Xihua ChenNHC Key Laboratory of Reproductive Health Engineering Technology Research, Department of Reproduction and Physiology, National Research Institute for Family Planning, Beijing, 100081, China.
Taifeng ZhuangBeijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, 100026, China.
Xiangbo XuNHC Key Laboratory of Reproductive Health Engineering Technology Research, Department of Reproduction and Physiology, National Research Institute for Family Planning, Beijing, 100081, China.
Yufeng ZhengSchool of Materials Science and Engineering, Peking University, Beijing, 100871, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endometrial injury and resulting female infertility pose significant clinical challenges due to the notable shortcomings of traditional treatments. Herein, we proposed a double network composite hydrogel, CSMA-RC-Zn-PNS, which forms a physical barrier on damaged tissue through photo-crosslinking while enabling sustained release of the active ingredient PNS. Based on this, we developed a combined strategy to enhance transdermal delivery efficiency using ultrasound cavitation.

Indexed as

Double network hydrogelEndometrium regenerationFertility recoveryTransdermal deliveryUltrasound cavitation effect

Identifiers

PMID40270550
PMCPMC12017869

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.