Evidence map›Paper›PMID 40270580›Full record

ArticleJID innovations : skin science from molecules to population health2025

Carvedilol Prevents UV-Induced Immunosuppression and Skin Carcinogenesis through a Mechanism Independent of β-Blockade.

Ayaz Shahid, Fanglong Dong, Bradley T Andresen, Ying Huang

Abstract read
In one paragraph

Article in JID innovations : skin science from molecules to population health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ayaz ShahidDepartment of Biotechnology and Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA.
Fanglong DongCollege of Podiatric Medicine, Western University of Health Science, Pomona, California, USA.
Bradley T AndresenDepartment of Biotechnology and Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA.
Ying HuangDepartment of Biotechnology and Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA.

Funding

Preventing UV-induced immunosuppression and skin carcinogenesis with R-carvedilolR01CA269653 · NCI · WESTERN UNIVERSITY OF HEALTH SCIENCES · PI Ying Huang · 2022 to 2026
$1.6M
Topical delivery of non-β-blocking R-carvedilol for prevention of UV-induced skin cancerR15CA227946 · NCI · WESTERN UNIVERSITY OF HEALTH SCIENCES · PI HUANG, YING · 2018 to 2018
$409k
NCI NIH HHS R01 CA269653NCI NIH HHS R15 CA227946
6 · The paper itself

Abstract

Exposure to UVR suppresses the immune system, which plays a primary role in skin cancer etiology. The β-blocker carvedilol prevents UV-induced skin cancer, but the mechanism is unknown. This study examined the effects of carvedilol and its enantiomers on UV-induced immunosuppression using contact hypersensitivity (CHS) response in SKH-1 mice. A single-dose UVR (224 mJ/cm

Indexed as

CarvedilolImmunosuppressionSkin cancerUVRβ-Blocker

Identifiers

PMID40270580
PMCPMC12017990

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.