ArticleJournal of biomedical optics2025
Portable multi-parametric microscopy for noninvasive metabolic and vascular imaging of orthotopic tongue cancer models
Article in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Introduction to Special Issue on Metabolic Imaging and Spectroscopy, 2025.Journal of biomedical optics · 2025Article
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Authors and funding
3 authors.
Funding
Abstract
Significance: Precise imaging of tumor metabolism with its vascular microenvironment becomes emerging critical for cancer research because increasing evidence shows that the key attribute that allows a tumor to survive therapies is metabolic and vascular reprogramming. However, there are surprisingly few imaging techniques available to provide a systems-level view of tumor metabolism and vasculature Aim: We aim to develop a new multi-parametric microscope that can faithfully recapitulate Approach: We have combined fluorescence microscopy and dark-field microscopy in a re-emission geometry into one portable microscope to image the key metabolic and vascular endpoints on the same tissue site. The portable microscope was first characterized by tissue-mimicking phantoms. Then the multi-parametric system was demonstrated on small animals to image glucose uptake (using 2-NBDG) and mitochondrial membrane potential (using TMRE) along with vascular parameters (oxygen saturation and hemoglobin contents) of orthotopic tongue tumors Results: Our phantom studies demonstrated the capability of the portable microscope for effective measurements of several key vascular and metabolic parameters with a comparable accuracy compared with our former reported benchtop spectroscopy and imaging systems. Our Conclusions: Our
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Registered trials
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