Evidence map›Paper›PMID 40273582›Full record

ArticleHormones and behavior2025

Interplay between prenatal bisphenol exposure, postnatal maternal care, and offspring sex in predicting DNA methylation relevant to anxiety-like behavior in rats.

Samantha C Lauby, Isha Agarwal, Hannah E Lapp, Melissa Salazar, Sofiia Semyrenko, Danyal Chauhan, Amy E Margolis, Frances A Champagne

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hormones and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Postnatal maternal care impacts hypothalamicbioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samantha C LaubyDepartment of Psychology, College of Liberal Arts, University of Texas at Austin, Austin, TX, United States of America; Center for Molecular Carcinogenesis and Toxicology, University of Texas at Austin, Austin, TX, United States of America.
Isha AgarwalDepartment of Psychology, College of Liberal Arts, University of Texas at Austin, Austin, TX, United States of America.
Hannah E LappDepartment of Psychology, College of Liberal Arts, University of Texas at Austin, Austin, TX, United States of America.
Melissa SalazarDepartment of Psychology, College of Liberal Arts, University of Texas at Austin, Austin, TX, United States of America.
Sofiia SemyrenkoDepartment of Psychology, College of Liberal Arts, University of Texas at Austin, Austin, TX, United States of America.
Danyal ChauhanDepartment of Psychology, College of Liberal Arts, University of Texas at Austin, Austin, TX, United States of America.
Amy E MargolisDepartment of Psychiatry, The Ohio State Univeristy, Columbus, OH, United States of America.
Frances A ChampagneDepartment of Psychology, College of Liberal Arts, University of Texas at Austin, Austin, TX, United States of America; Center for Molecular Carcinogenesis and Toxicology, University of Texas at Austin, Austin, TX, United States of America. Electronic address: franceschampagne@utexas.edu.

Funding

Environmental bisphenol exposure, infant brain and behavior: Human and animal modelsR01ES030950 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI VEENSTRA-VANDERWEELE, JEREMY · 2020 to 2023
$2.6M
Interactive Effects of Prenatal Bisphenol Exposure and Postnatal Maternal Care on DNA Methylation in the Developing BrainF32ES035254 · NIEHS · UNIVERSITY OF TEXAS AT AUSTIN · PI LAUBY, SAMANTHA · 2023 to 2025
$233k
NIEHS NIH HHS F32 ES035254NIEHS NIH HHS R01 ES030950
6 · The paper itself

Abstract

Prenatal exposure to endocrine disrupting chemicals, such as bisphenols, can alter neurodevelopmental trajectories and have a lasting neurobehavioral impact through epigenetic pathways. However, outcomes associated with prenatal bisphenol exposure may also be shaped by the postnatal environment and collectively these environmental effects may be sex-specific. Thus, an integrative research design that includes multiple early life exposures and considers sex differences may be essential for predicting outcomes. In the current study, we use a multivariate approach to examine the contributions of prenatal bisphenol exposure, postnatal maternal care, and offspring sex to variation in DNA methylation of well-studied candidate genes (NR3C1, BDNF, OXTR) in the ventral hippocampus and amygdala of adult Long-Evans rats. Main effects of postnatal maternal care and interactions with prenatal bisphenol exposure were consistently found for DNA methylation within the NR3C1 gene (ventral hippocampus) and within the BDNF and OXTR genes (amygdala). Sex-specific effects were also found across all analyses. Overall, our findings suggest that both early-life factors (prenatal and postnatal) and offspring sex contribute to variation in DNA methylation in genes and brain regions relevant for the expression of anxiety-like behavior. These results highlight the need to consider the brain region-specific effects of multiple exposures in males and females to understand the lasting effects of early environments.

Indexed as

AnxietyBenzhydryl CompoundsDNA MethylationEndocrine DisruptorsMaternal BehaviorPhenolsPrenatal Exposure Delayed EffectsAmygdalaAnimalsBehavior, AnimalBisphenol A CompoundsBrain-Derived Neurotrophic FactorFemaleHippocampusMalePregnancyBdnf protein, ratBenzhydryl Compoundsbisphenol ABisphenol A CompoundsBrain-Derived Neurotrophic FactorEndocrine DisruptorsNR3C1 protein, ratPhenolsReceptors, GlucocorticoidReceptors, OxytocinAmygdalaAnxiety-like behaviorBDNFBisphenolsDNA methylationMaternal careNR3C1OXTRSex differencesVentral hippocampus

Identifiers

PMID40273582
PMCPMC12129672

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.