Evidence map›Paper›PMID 40273913›Full record

ArticleCurrent biology : CB2025

The neuropeptide FLP-11 induces and self-inhibits sleep through the receptor DMSR-1 in Caenorhabiditis elegans.

Lorenzo Rossi, Kenneth Amoako, Inka Busack, Luca Golinelli, Amy Courtney, Judith Besseling, William Schafer, Isabel Beets, Henrik Bringmann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Science advances · 2026
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lorenzo RossiBiotechnology Center, Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Am Tatzberg 47/49, 01307 Dresden, Germany.
Kenneth AmoakoBiotechnology Center, Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Am Tatzberg 47/49, 01307 Dresden, Germany.
Inka BusackBiotechnology Center, Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Am Tatzberg 47/49, 01307 Dresden, Germany.
Luca GolinelliDepartment of Biology, KU Leuven, Naamsestraat 59, 3000 Leuven, Belgium.
Amy CourtneyMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
Judith BesselingMax Planck Institute of Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
William SchaferDepartment of Biology, KU Leuven, Naamsestraat 59, 3000 Leuven, Belgium; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
Isabel BeetsDepartment of Biology, KU Leuven, Naamsestraat 59, 3000 Leuven, Belgium.
Henrik BringmannBiotechnology Center, Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Am Tatzberg 47/49, 01307 Dresden, Germany; Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany. Electronic address: henrik.bringmann@tu-dresden.de.

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Medical Research Council MC_U105185857NIH HHS P40 OD010440
6 · The paper itself

Abstract

Sleep is caused by the depolarization of sleep-active neurons, which secrete gamma-aminobutyric acid (GABA) and neuropeptides such as conserved RFamide (c-terminal Arg-Phe-NH

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsNeuropeptidesReceptors, G-Protein-CoupledSleepAnimalsNeuronsCaenorhabditis elegans ProteinsNeuropeptidesReceptors, G-Protein-Coupledcalcium imagingC. elegansDMSR-1FLP-11Gi/oGPCRhomeostasisoptogeneticsRFamidesleep

Identifiers

PMID40273913
PMCPMC7617803

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.