Evidence map›Paper›PMID 40274765›Full record

ArticleNature communications2025

Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins.

Sandra Zakrzewska, Samantha A Nixon, Zhou Chen, Holly S Hajare, Elizabeth R Park, John V Mulcahy, Kandis M Arlinghaus, Eduard Neu, Kirill Konovalov, Davide Provasi and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Saxiphilin is a broad-spectrum toxin sponge for C13-modified saxitoxins.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sandra ZakrzewskaCardiovascular Research Institute, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8706-4394
Samantha A NixonCardiovascular Research Institute, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-3157-4114
Zhou ChenCardiovascular Research Institute, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-4426-2497
Holly S HajareDepartment of Chemistry, Stanford University, Stanford, CA, USA.
Elizabeth R ParkDepartment of Chemistry, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9974-3899
John V MulcahyDepartment of Chemistry, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-3997-6073
Kandis M ArlinghausNational Oceanic and Atmospheric Administration, National Centers for Coastal Ocean Science, Charleston, SC, USA.
Eduard NeuDepartment of Pharmacological Sciences, Ichan School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-2999-1488
Kirill KonovalovDepartment of Pharmacological Sciences, Ichan School of Medicine at Mount Sinai, New York, NY, USA.
Davide ProvasiDepartment of Pharmacological Sciences, Ichan School of Medicine at Mount Sinai, New York, NY, USA.
Tod A LeighfieldNational Oceanic and Atmospheric Administration, National Centers for Coastal Ocean Science, Charleston, SC, USA.
Marta FilizolaDepartment of Pharmacological Sciences, Ichan School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-4382-8276
J Du BoisDepartment of Chemistry, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-7847-1548
Daniel L MinorCardiovascular Research Institute, University of California, San Francisco, CA, USA. daniel.minor@ucsf.edu.ORCID http://orcid.org/0000-0002-5998-4214

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
Guanidinium Toxins as Molecular Probes for NaV StudyR01GM117263 · NIGMS · STANFORD UNIVERSITY · PI DU BOIS, JUSTIN · 2016 to 2024
$3.5M
COVID and Translational Science supercomputer (CATS)S10OD030463 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2021 to 2021
$2.0M
Big Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M
NCATS NIH HHS UL1 TR004419NIGMS NIH HHS R01 GM117263NIH HHS S10 OD026880NIH HHS S10 OD030463United States Department of Defense | Defense Threat Reduction Agency (DTRA) HDTRA-1-19-1-0040United States Department of Defense | Defense Threat Reduction Agency (DTRA) HDTRA 1 21-1-0011United States Department of Defense | Defense Threat Reduction Agency (DTRA) HDTRA-1-23-1-0026U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR004419U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01 GM117263 05
6 · The paper itself

Abstract

Dinoflagellates and cyanobacteria produce saxitoxin (STX) and ~50 congeners that disrupt bioelectrical signals by blocking voltage-gated sodium channels (Na

Indexed as

AnuraCarrier ProteinsSaxitoxinAnimalsDinoflagellidaProtein BindingRana catesbeianaVoltage-Gated Sodium ChannelsCarrier ProteinsSaxitoxinVoltage-Gated Sodium Channels

Identifiers

PMID40274765
PMCPMC12022044

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.