ReviewCurrent pharmaceutical design2025
Nanoemulsion Technology in Oral Drug Delivery: A Path to Enhanced Solubility and Bioavailability.
Review in Current pharmaceutical design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Camptothecin Nanoformulations: Recent Advances in Preparation, Bioactivities, and Clinical Perspectives.Annals of biomedical engineering · 2026Review
- Antibacterial and Antifungal Properties ofPharmaceuticals (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanoemulsions (NEs) are submicron-sized colloidal dispersions (20-500 nm) consisting of oil and aqueous phases stabilized by surfactants and cosurfactants. Despite their thermodynamic instability, NEs maintain kinetic stability, preventing separation and aggregation. This stability distinguishes them from microemulsions, which are thermodynamically stable and formed spontaneously. The emulsification process involves a reduction in Gibbs surface free energy facilitated by emulsifiers that lower interfacial tension, crucial for compensating for the high surface area associated with small droplet sizes. The Gibbs free energy reduction is vital as it helps in stabilizing nanoemulsions, while Laplace pressure, resulting from the curvature of the droplets, affects the stability and uniformity of the system. High Laplace pressures in smaller droplets can lead to coalescence, but the proper formulation with suitable surfactants can help mitigate this effect. This review investigates the hypothesis that NEs can significantly enhance the solubility and bioavailability of hydrophobic drugs by optimizing their formulation and stability. We focus on the role of emulsification techniques in creating stable nanoemulsions, with particular attention to the impact of hydrophilic-lipophilic balance (HLB) and critical packing parameters (CPP) on droplet size and stability. Furthermore, we provide a detailed comparison of various preparation methods, including ultrasonication and high-pressure homogenization, emphasizing their influence on droplet size, stability, and scalability. Experimental data from in vitro and in vivo studies illustrate the advantages of NEs for oral drug delivery, with findings showing significant improvements in bioavailability for poorly soluble drugs, such as paclitaxel and curcumin, under optimized formulation conditions. This review highlights the potential of NEs to overcome the limitations of traditional drug delivery systems and provides a roadmap for future research to improve their commercial viability and therapeutic outcomes.
Indexed as
Identifiers
40277115What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.