Evidence map›Paper›PMID 40277177›Full record

ArticleIUCrJ2025

Instrumentation and methods for efficient time-resolved X-ray crystallography of biomolecular systems with sub-10 ms time resolution.

John A Indergaard, Kashfia Mahmood, Leo Gabriel, Gary Zhong, Adam Lastovka, Matthew J McLeod, Robert E Thorne

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IUCrJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

John A IndergaardPhysics Department, Cornell University, 142 Sciences Drive, Ithaca, NY 14850, USA.ORCID 0000-0002-2367-699X
Kashfia MahmoodPhysics Department, Cornell University, 142 Sciences Drive, Ithaca, NY 14850, USA.ORCID 0009-0001-4457-6656
Leo GabrielPhysics Department, Cornell University, 142 Sciences Drive, Ithaca, NY 14850, USA.
Gary ZhongPhysics Department, Cornell University, 142 Sciences Drive, Ithaca, NY 14850, USA.ORCID 0009-0003-5035-3752
Adam LastovkaPhysics Department, Cornell University, 142 Sciences Drive, Ithaca, NY 14850, USA.ORCID 0009-0004-1167-135X
Matthew J McLeodPhysics Department, Cornell University, 142 Sciences Drive, Ithaca, NY 14850, USA.ORCID 0000-0001-5540-916X
Robert E ThornePhysics Department, Cornell University, 142 Sciences Drive, Ithaca, NY 14850, USA.ORCID 0000-0002-7489-8074

Funding

X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Vivian Stojanoff · 2019 to 2026
$38.6M
Training and OutreachP30GM124166 · NIGMS · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2019 to 2026
$28.3M
National Institutes of Health, National Center for Research Resources P30-GM124166-01A1National Institutes of Health, National Institute of General Medical Sciences P30GM133893National Science Foundation, Directorate for Biological Sciences DBI-2210041National Science Foundation, Directorate for Mathematical and Physical Sciences DMR-1829070NIGMS NIH HHS P30 GM124166NIGMS NIH HHS P30 GM133893U.S. Department of Energy, Office of Science DE-SC0012704U.S. Department of Energy, Office of Science KP1605010
6 · The paper itself

Abstract

Time-resolved X-ray crystallography has great promise to illuminate structure-function relations and key steps of enzymatic reactions with atomic resolution. The dominant methods for chemically-initiated reactions require complex instrumentation at the X-ray beamline, significant effort to operate and maintain this instrumentation, and enormous numbers (∼10

Indexed as

Crystallography, X-RayMuramidaseSynchrotronsTime FactorsMuramidaseenzyme mechanismmix and quenchprotein dynamicstime-resolved cryo-EMtime-resolved crystallography

Identifiers

PMID40277177
PMCPMC12044851

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.