Evidence map›Paper›PMID 40277521›Full record

ArticleBiosensors2025

A Planar-Gate Graphene Field-Effect Transistor Integrated Portable Platform for Rapid Detection of Colon Cancer-Derived Exosomes.

Zaiyu Zhang, Luyang Zhang, Yuting Huang, Ziran Wang, Zhongjing Ren

Abstract read
In one paragraph

Article in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zaiyu ZhangKey Laboratory of High-Efficiency and Clean Mechanical Manufacture, Ministry of Education, Department of Mechanical Engineering, Shandong University, Jinan 250100, China.
Luyang ZhangKey Laboratory of High-Efficiency and Clean Mechanical Manufacture, Ministry of Education, Department of Mechanical Engineering, Shandong University, Jinan 250100, China.
Yuting HuangDepartment of Clinical Laboratory, Qilu Hospital of Shandong University, Jinan 250012, China.
Ziran WangKey Laboratory of High-Efficiency and Clean Mechanical Manufacture, Ministry of Education, Department of Mechanical Engineering, Shandong University, Jinan 250100, China.
Zhongjing RenKey Laboratory of High-Efficiency and Clean Mechanical Manufacture, Ministry of Education, Department of Mechanical Engineering, Shandong University, Jinan 250100, China.ORCID 0000-0002-8927-5777

Funding

China Postdoctoral Science Foundation 2023MD744219Excellent Youth Science Fund Project (Overseas) of Shandong Province, China 2023HWYQ 029National Natural Science Foundation of China No. 52305606Natural Science Foundation of Jiangsu Province No. BK20230254Qilu Young Scholars Program of Shandong University, State Key Laboratory of Robotics and System (HIT) No. SKLRS-2023-KF-03Shandong Provincial Natural Science Foundation No. ZR2023QE187Taishan Scholars Project of Shandong Province No. tsqn202306028Youth Project of Natural Science Foundation of Shandong Province, China ZR2023QE127Zhejiang Province Selected Funding for Postdoctoral Research Projects ZJ2023040
6 · The paper itself

Abstract

Early diagnosis of diseases would significantly increase the survival rate of cancer patients. However, current screening methods are complex and costly, making them unsuitable for rapid health diagnosis in daily life. Here, we develop a portable platform based on a planar-gate graphene field-effect transistor functionalized with polydopamine self-assembled film (PDA-GFET), capable of identifying colon cancer through the detection of EpCAM protein, which is expressed on colon cancer-derived exosomes, in clinical samples within 10 min. The PDA self-assembled film on the graphene and gate surface enhances the biosensor's functionalization area while suppressing non-specific adsorption, thereby achieving detection limits as low as 112 particles/mL. In addition, the PDA-GFET-based detection platform was used to identify EpCAM protein in real clinical samples from healthy individuals and colon cancer patients within 10 min, and the two showed significant differences (

Indexed as

Biosensing TechniquesColonic NeoplasmsExosomesGraphiteEpithelial Cell Adhesion MoleculeHumansIndolesLimit of DetectionPolymersTransistors, ElectronicEpithelial Cell Adhesion MoleculeGraphiteIndolespolydopaminePolymerscolon cancer diagnosisexosome detectionGFET biosensorpolydopamine

Identifiers

PMID40277521
PMCPMC12025066

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.