Evidence mapPaperPMID 40278191Full record

ArticleJournal of cardiovascular development and disease2025

Decreased Endothelial Progenitor Cells Are Associated with Severe Coronary Artery Disease: Insights from a Clinical Study.

Ivan Tomić, Ivan Zeljko, Ivica Brizić, Violeta Šoljić, Ivona Ivančić, Monika Tomić, Marina Ćurlin, Domagoj Tomić

Abstract read
In one paragraph

Article in Journal of cardiovascular development and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ivan TomićDepartment of Internal Medicine, University Clinical Hospital Mostar, Kralja Tvrtka bb, 88000 Mostar, Bosnia and Herzegovina.ORCID 0000-0001-8894-2518
Ivan ZeljkoDepartment of Internal Medicine, University Clinical Hospital Mostar, Kralja Tvrtka bb, 88000 Mostar, Bosnia and Herzegovina.
Ivica BrizićDepartment of Internal Medicine, University Clinical Hospital Mostar, Kralja Tvrtka bb, 88000 Mostar, Bosnia and Herzegovina.
Violeta ŠoljićFaculty of Health Study, University of Mostar, Trg Hrvatskih Velikana 1, 88000 Mostar, Bosnia and Herzegovina.
Ivona IvančićFaculty of Pharmacy, University of Mostar, Trg Hrvatskih Velikana 1, 88000 Mostar, Bosnia and Herzegovina.
Monika TomićDepartment of Internal Medicine, University Clinical Hospital Mostar, Kralja Tvrtka bb, 88000 Mostar, Bosnia and Herzegovina.
Marina ĆurlinFaculty of Health Study, University of Mostar, Trg Hrvatskih Velikana 1, 88000 Mostar, Bosnia and Herzegovina.ORCID 0009-0000-5615-2722
Domagoj TomićHealth Centre Široki Brijeg, Dr. Jure Grubišića 11, 88220 Široki Brijeg, Bosnia and Herzegovina.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endothelial progenitor cells (EPCs) play a crucial role in vascular repair, and their depletion has been involved in coronary artery disease (CAD) severity. This study examines the relationship between circulating EPC levels and CAD complexity, as quantified by the Syntax Score I. A total of 85 patients undergoing coronary angiography were enrolled, with EPCs quantified using flow cytometry. EPC proportion showed a significant inverse relationship with CAD severity, measured by Syntax Score I. Additionally, we investigated EPC levels in patients presenting with acute coronary syndrome (ACS) and found that EPC depletion was more pronounced in this group compared to non-ACS patients (median EPC count: 0.35 vs. 0.61,

Indexed as

acute coronary syndromebiomarkercoronary artery diseaseendothelial progenitor cellsSyntax Scorevascular repair

Identifiers

PMID40278191
PMCPMC12028075

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.