Evidence map›Paper›PMID 40278255›Full record

ArticleJournal of functional biomaterials2025

MicroRNA-210 Enhances Cell Survival and Paracrine Potential for Cardiac Cell Therapy While Targeting Mitophagy.

Rita Alonaizan, Ujang Purnama, Sophia Malandraki-Miller, Mala Gunadasa-Rohling, Andrew Lewis, Nicola Smart, Carolyn Carr

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of functional biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rita AlonaizanDepartment of Physiology, Anatomy & Genetics, University of Oxford, Oxford OX1 3PT, UK.ORCID 0000-0003-1118-5015
Ujang PurnamaDepartment of Physiology, Anatomy & Genetics, University of Oxford, Oxford OX1 3PT, UK.ORCID 0000-0003-0513-3294
Sophia Malandraki-MillerDepartment of Physiology, Anatomy & Genetics, University of Oxford, Oxford OX1 3PT, UK.
Mala Gunadasa-RohlingDepartment of Physiology, Anatomy & Genetics, University of Oxford, Oxford OX1 3PT, UK.
Andrew LewisDepartment of Physiology, Anatomy & Genetics, University of Oxford, Oxford OX1 3PT, UK.
Nicola SmartDepartment of Physiology, Anatomy & Genetics, University of Oxford, Oxford OX1 3PT, UK.ORCID 0000-0002-3501-7254
Carolyn CarrDepartment of Physiology, Anatomy & Genetics, University of Oxford, Oxford OX1 3PT, UK.ORCID 0000-0003-0102-5261

Funding

King Faisal Specialist Hospital & Research Centre Doctoral scholarship to Rita Alonaizan
6 · The paper itself

Abstract

The therapeutic potential of presumed cardiac progenitor cells (CPCs) in heart regeneration has garnered significant interest, yet clinical trials have revealed limited efficacy due to challenges in cell survival, retention, and expansion. Priming CPCs to survive the hostile hypoxic environment may be key to enhancing their regenerative capacity. We demonstrate that microRNA-210 (miR-210), known for its role in hypoxic adaptation, significantly improves CPC survival by inhibiting apoptosis through the downregulation of

Indexed as

cardiac progenitor cellscell therapyheart regenerationhypoxiaischaemiamiR-210mitophagymyocardial infarction

Identifiers

PMID40278255
PMCPMC12028018

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.