Evidence map›Paper›PMID 40278296›Full record

ArticleMarine drugs2025

Epicoccin A Ameliorates PD-like Symptoms in Zebrafish: Enhancement of PINK1/Parkin-Dependent Mitophagy and Inhibition of Excessive Oxidative Stress.

Haicheng Ye, Dan Li, Lei Zhang, Yufei Wang, Cong Wang, Meng Jin, Houwen Lin, Peihai Li, Chen Sun, Ning Li

Abstract read
In one paragraph

Article in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Haicheng YeShandong Academy of Sciences & Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Biology Institute, Qilu University of Technology, Jinan 250000, China.
Dan LiShandong Academy of Sciences & Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Biology Institute, Qilu University of Technology, Jinan 250000, China.
Lei ZhangShandong Overseas Fisheries Association, Jinan 250000, China.
Yufei WangKey Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission & Guangxi Key Laboratory of Chemistry and Engineering of Forest Products/Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, Guangxi Minzu University, Nanning 530000, China.
Cong WangKey Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission & Guangxi Key Laboratory of Chemistry and Engineering of Forest Products/Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, Guangxi Minzu University, Nanning 530000, China.
Meng JinShandong Academy of Sciences & Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Biology Institute, Qilu University of Technology, Jinan 250000, China.ORCID 0000-0002-1525-0876
Houwen LinResearch Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, School of Medicine, Shanghai Jiao Tong University, Shanghai 200000, China.ORCID 0000-0002-7097-0876
Peihai LiShandong Academy of Sciences & Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Biology Institute, Qilu University of Technology, Jinan 250000, China.
Chen SunShandong Academy of Sciences & Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Biology Institute, Qilu University of Technology, Jinan 250000, China.ORCID 0000-0002-8033-1357
Ning LiShandong Academy of Sciences & Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Biology Institute, Qilu University of Technology, Jinan 250000, China.

Funding

Foundation of National Key R&D Program of China 2022YFC2804100General Program of Shandong Provincial Natural Science Foundation ZR2022MD102Innovation Ability Improvement Project of Small and Medium-sized Sci-Tech Enterprises in Shandong Province 2023TSGC0851
6 · The paper itself

Abstract

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, yet effective agents for its prevention and therapy remain highly limited. Epicoccin A, a significant secondary metabolite from

Indexed as

MitophagyNeuroprotective AgentsOxidative StressParkinson DiseaseUbiquitin-Protein LigasesZebrafish ProteinsAnimalsDisease Models, AnimalDopaminergic NeuronsMolecular Docking SimulationProtein KinasesProtein Serine-Threonine KinasesPTEN-Induced Putative KinaseReactive Oxygen SpeciesZebrafishNeuroprotective Agentsparkin proteinPink1 protein, zebrafishProtein KinasesProtein Serine-Threonine KinasesPTEN-Induced Putative KinaseReactive Oxygen SpeciesUbiquitin-Protein LigasesZebrafish Proteinsmarine-derived fungusmolecular dockingMPTPneuroprotective effectROStranscriptome analysisunderlying mechanismα-synuclein

Identifiers

PMID40278296
PMCPMC12028493

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.