Evidence map›Paper›PMID 40278833›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

METTL14-Induced M

Qiantao Zheng, Xiao Zhong, Qianqian Kang, Zhiguo Zhang, Decheng Ren, Yong Liu, Liangyou Rui

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. The Role of NMedComm · 2026
    Review
  3. POMC neuron METTL14/mNature communications · 2026
    Article
  4. Article
  5. METTL14-Induced MAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qiantao ZhengDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Xiao ZhongDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Qianqian KangDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Zhiguo ZhangDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Decheng RenDepartment of Medicine, University of Chicago, Chicago, IL, 60637, USA.
Yong LiuCollege of Life Sciences, Wuhan University, Wuhan, 430072, China.
Liangyou RuiDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.ORCID https://orcid.org/0000-0001-8433-8137

Funding

PUBLIC HEALTH DEMONSTRATIONP60DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MYERS, MARTIN G · 1985 to 2012
$26.5M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MERCHANT, JUANITA L. · 1986 to 2021
$22.5M
Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Karen Eileen Peterson · 2010 to 2026
$20.3M
The Role of Hypothalamic Slug in the Regulation of Leptin Sensitivity, Energy Balance, and Body WeightR01DK114220 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RUI, LIANGYOU · 2017 to 2024
$4.2M
Role of adipose mRNA modifications in metabolic diseaseR01DK130111 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIANGYOU RUI · 2022 to 2026
$2.4M
Role of hypothalamic SH2B1 neurocircuits and SH2B1 signal transduction pathways in obesity and metabolic diseaseR01DK141559 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIANGYOU RUI · 2025 to 2026
$1.4M
Role of hepatic Mettl14 pathways in liver metabolism and body metabolic homeostasisR01DK127568 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RUI, LIANGYOU · 2021 to 2023
$1.2M
American Heart Association 831585Michigan Diabetes Research and Training Center NIH DK020572Michigan Metabolomics and Obesity Center DK089503NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK034933NIDDK NIH HHS P30 DK089503NIDDK NIH HHS P60 DK020572NIDDK NIH HHS R01 DK114220NIDDK NIH HHS R01DK114220NIDDK NIH HHS R01 DK127568NIDDK NIH HHS R01DK127568NIDDK NIH HHS R01 DK130111NIDDK NIH HHS R01DK130111NIDDK NIH HHS R01 DK141559NIDDK NIH HHS R01DK141559-01University of Michigan Center for Gastrointestinal Research NIDDK P30DK034933
6 · The paper itself

Abstract

METTL14 dimerizes with METTL3 to install N6-methyladenosine (m

Indexed as

GlucoseGlucose-6-PhosphataseLiverMetabolic DiseasesMethyltransferasesObesityAdenosineAnimalsGluconeogenesisHepatocytesHumansMaleMethylationMiceMice, Inbred C57BLMice, KnockoutAdenosineGlucoseGlucose-6-PhosphataseMethyltransferasesMettl14 protein, mouseMettl3 protein, mouseN-methyladenosineRNA, MessengerG6pcgluconeogenesishepatic glucose productionm6A, METTL14obesitytype 2 diabetesYTHDF1YTHDF3

Identifiers

PMID40278833
PMCPMC12165098

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.