Evidence map›Paper›PMID 40279474›Full record

ArticleACS synthetic biology2025

Modulating the Properties of GPCR-Based Sensors Via C-Terminus Isoforms.

Paola L Marquez-Gomez, Sonia R Damiano, Lily R Torp, Pamela Peralta-Yahya

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS synthetic biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Paola L Marquez-GomezSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Sonia R DamianoSchool of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Lily R TorpSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Pamela Peralta-YahyaSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.ORCID 0000-0002-0356-2274

Funding

Olfactory receptor-based sensors for biomedical applicationsR35GM124871 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI Pamela Peralta-Yahya · 2017 to 2026
$3.6M
NIGMS NIH HHS R35 GM124871
6 · The paper itself

Abstract

G-protein coupled receptors (GPCRs) play a key role in chemical biosensing, detecting chemicals from odorants and hormones to neurotransmitters and peptides. GPCR-based sensors in yeast can be rapidly engineered by coupling human GPCRs to the yeast mating pathway, resulting in cell fluorescence or luminescence upon chemical detection. Modulating the properties of GPCR-based sensors including their dynamic and linear ranges is nontrivial, often requiring the engineering of the yeast cell machinery. Here, we explore the use of GPCR C-terminal isoforms to modulate the properties of chemical biosensors. As a proof-of-concept, we leverage nine naturally occurring serotonin receptor 4 (5-HTR

Indexed as

Biosensing TechniquesReceptors, G-Protein-CoupledReceptors, Serotonin, 5-HT4HumansProtein IsoformsSaccharomyces cerevisiaeSerotoninProtein IsoformsReceptors, G-Protein-CoupledReceptors, Serotonin, 5-HT4SerotoninGPCRisoformssensorsserotoninyeast

Identifiers

PMID40279474
PMCPMC12090342

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.