ArticleScientific reports2025
Punicalagin relieves hepatic injury by antioxidation and enhancement of autophagy in diet-induced nonalcoholic steatohepatitis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Targeting amino acid metabolic pathways: a novel therapeutic strategy for hyperuricemia-associated complications.Amino acids · 2026Review
- The therapeutic potential of botanicals: how medicinal plants targeting autophagy can reverse metabolic-associated fatty liver disease.Frontiers in pharmacology · 2026Review
- Targeting Lipophagy in Liver Diseases: Impact on Oxidative Stress and Steatohepatitis.Antioxidants (Basel, Switzerland) · 2025Review
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4 authors.
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Abstract
Hepatic injury induced by many factors play a central role in the pathogenesis of liver diseases. Punicalagin (PUN) is a major antioxidant polyphenolic compound extracted from pomegranates. The aim of this study was to investigate the potential role of PUN on liver injury induced by nonalcoholic steatohepatitis (NASH). Therefore, the effects and mechanistic action of PUN on NASH mouse model induced by choline-deficient, L-amino acid- defined, high-fat (CDAAH) diet were investigated in vivo. Wild-type or nuclear erythroid 2-related factor 2 (Nrf2) KO mice were fed with CDAAH diet to induce NASH and then treated with PUN (100, 300 or 500 mg kg
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