Evidence map›Paper›PMID 40281250›Full record

Trial reportObesity surgery2025

The Effects of Intraperitoneal Dexmedetomidine in Comparison with Ropivacaine in Postoperative Pain After Laparoscopic Sleeve Gastrectomy: A Double-Blind, Randomized, Placebo-Controlled, Clinical Trial.

Mohamadreza Neishaboury, Samira Shokri, Parisa Kianpour, Kousha Farhadi, Khosrow Najjari, Hamidreza Sharifnia, Rana MohammadYousef, Mohammadreza Khajavi

Abstract readRandomized Controlled TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in Obesity surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohamadreza NeishabouryDepartment of Anesthesiology and Critical Care, School of Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Tehran, Iran, Islamic Republic of.
Samira ShokriDepartment of Anesthesiology and Critical Care, School of Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Tehran, Iran, Islamic Republic of.
Parisa KianpourAnesthesia, Critical Care, and Pain Management Research Center, Tehran University of Medical Sciences, Tehran, Tehran, Iran, Islamic Republic of. parisa_kianpour@yahoo.com.
Kousha FarhadiAnesthesia, Critical Care, and Pain Management Research Center, Tehran University of Medical Sciences, Tehran, Tehran, Iran, Islamic Republic of.
Khosrow NajjariDepartment of General Surgery, School of Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Tehran, Iran, Islamic Republic of.
Hamidreza SharifniaDepartment of Anesthesiology and Critical Care, School of Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Tehran, Iran, Islamic Republic of.
Rana MohammadYousefDepartment of Anesthesiology and Critical Care, School of Medicine, Childrens Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Tehran, Iran, Islamic Republic of.
Mohammadreza KhajaviDepartment of Anesthesiology and Critical Care, School of Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Tehran, Iran, Islamic Republic of. khajavim@tums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies have shown that non-opioid analgesic drugs can reduce the pain of patients after bariatric surgery. Ropivacaine and dexmedetomidine are associated with high efficacy and safety in managing postoperative complications. We evaluated the effectiveness of ropivacaine alone and in combination with dexmedetomidine in improving outcomes after sleeve gastrectomy surgery.

methodsThis double-blind, randomized clinical trial, included patients undergoing bariatric surgery in 2022 and 2023. The participants were randomly divided into three groups: treated with ropivacaine alone (group A), ropivacaine and dexmedetomidine combination (group B), or normal saline (group C). Pain scores, morphine consumption, and postoperative nausea and vomiting (PONV) were assessed over 24 h.

resultsAll groups showed reduced pain, but group B had significantly lower VAS scores than groups A and C at 4-24 h postoperatively, with the highest difference achieved by group B compared to control at 12-h time point (β =  - 2.5, P < 0.001). Morphine use was lowest in group B (4.38 ± 1.24 mg vs. 6.04 ± 2.07 mg in group A and 7.50 ± 2.55 mg in group C; P < 0.001). PONV incidence was also lower in group B (8.3% vs. 29.2% in group A and 50% in group C; P = 0.008).

conclusionsThe ropivacaine and dexmedetomidine combination therapy was associated with a greater pain relief effect after sleeve gastrectomy, a greater reduction in the need to take opioids, and a lower frequency of PONV compared to the ropivacaine alone or placebo.

Indexed as

DexmedetomidineGastrectomyLaparoscopyObesity, MorbidPostoperative PainRopivacaineAdultAnalgesics, Non-NarcoticAnesthetics, LocalDouble-Blind MethodDrug Therapy, CombinationFemaleHumansMaleMiddle AgedMorphineAnalgesics, Non-NarcoticAnesthetics, LocalDexmedetomidineMorphineRopivacaineDexmedetomidineNauseaPainRopivacaineSleeve gastrectomyVomiting

Identifiers

PMID40281250

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.