Evidence map›Paper›PMID 40281267›Full record

ReviewJournal of thrombosis and thrombolysis2025

Atrial fibrillation and ischemic stroke in cancer: the latest scientific evidence, current management, and future directions.

Lakshya Seth, Nickolas Stabellini, Shawn Doss, Vraj Patel, Viraj Shah, Gregory Lip, Susan Dent, Michael G Fradley, Lars Køber, Avirup Guha

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of thrombosis and thrombolysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Thrombosis in patients with cancer: challenges and advances.Journal of thrombosis and thrombolysis · 2025
    Article
  3. The B-SCancers · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lakshya SethDepartment of Medicine, Division of Cardiology, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Nickolas StabelliniDepartment of Medicine, Division of Cardiology, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Shawn DossDepartment of Medicine, Division of Cardiology, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Vraj PatelDepartment of Medicine, Division of Cardiology, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Viraj ShahDepartment of Medicine, Division of Cardiology, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Gregory LipLiverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, UK.ORCID http://orcid.org/0000-0002-7566-1626
Susan DentWilmot Cancer Center, Department of Medicine, University of Rochester, Rochester, NY, USA.
Michael G FradleyThalheimer Center for Cardio-Oncology, Division of Cardiology, Department of Medicine Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lars KøberDepartment of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Avirup GuhaDepartment of Medicine, Division of Cardiology, Medical College of Georgia at Augusta University, Augusta, GA, USA. aguha@augusta.edu.

Funding

American Heart Association Strategically Focused Research Network Grant in Disparities in Cardio-Oncology 847740, 863620U.S. Department of Defense Prostate Cancer Research Program's Physician Research Award HT94252310158
6 · The paper itself

Abstract

Atrial fibrillation is the most common cardiac arrhythmia and is a major risk factor for ischemic stroke. Atrial fibrillation and ischemic stroke are major cardiovascular complications in cancer patients, who have a higher burden and worse outcomes than the general population. Clinical risk stratification scores for stroke and bleeding, commonly used in the general population to estimate thromboembolic and bleeding risk, respectively, are less well validated in cancer patients, who have historically been excluded in clinical trials. There is a lack of consensus opinion on how to effectively risk-stratify cancer patients based on the currently available tools and a need for cancer-specific scores that offer a tailored approach to each patient in order to more effectively stratify ischemic stroke and bleeding risk in this cohort of patients. Cancer-mediated physiologic changes and adverse effects of antineoplastic therapy have been implicated as etiologies of the increased risk for both atrial fibrillation and ischemic stroke. Risk stratifying scores such as CHA

Indexed as

Atrial FibrillationIschemic StrokeNeoplasmsHemorrhageHumansRisk AssessmentRisk Factors

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.