Evidence map›Paper›PMID 40281302›Full record

ReviewCurrent obesity reports2025

The Interplay of UCP3 and PCSK1 Variants in Severe Obesity.

Ludovica Verde, Martina Galasso, Dawn K Coletta, Silvia Savastano, Lawrence J Mandarino, Annamaria Colao, Luigi Barrea, Giovanna Muscogiuri

Abstract readReviewCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Review in Current obesity reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ludovica VerdeDepartment of Public Health, University of Naples Federico II, Via Sergio Pansini 5, 80131, Naples, Italy.
Martina GalassoDipartimento di Medicina Clinica e Chirurgia, Centro Italiano per la cura e il Benessere del Paziente con Obesità (C.I.B.O), Università degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131, Naples, Italy.
Dawn K ColettaDepartment of Medicine, Division of Endocrinology, University of Arizona, Tucson, AZ, USA.
Silvia SavastanoDipartimento di Medicina Clinica e Chirurgia, Centro Italiano per la cura e il Benessere del Paziente con Obesità (C.I.B.O), Università degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131, Naples, Italy.
Lawrence J MandarinoDepartment of Medicine, Division of Endocrinology, University of Arizona, Tucson, AZ, USA.
Annamaria ColaoDipartimento di Medicina Clinica e Chirurgia, Centro Italiano per la cura e il Benessere del Paziente con Obesità (C.I.B.O), Università degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131, Naples, Italy.
Luigi Barrea *Dipartimento di Psicologia e Scienze della Salute, , Università Telematica Pegaso, Centro Direzionale Isola F2, Via Porzio, Isola F2, 80143, Naples, Italy.
Giovanna Muscogiuri *Department of Medicine, Division of Endocrinology, University of Arizona, Tucson, AZ, USA. giovanna.muscogiuri@unina.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is a heterogeneous and multifactorial disease with a strong genetic component. While polygenic obesity accounts for most common cases, rare monogenic variants contribute, particularly in severe, early-onset obesity. Among the lesser-studied candidates are UCP3 and PCSK1, genes involved in key metabolic pathways. RECENT

findingsThe UCP3 p.Val192Ile (c.574G > A) and PCSK1 p.Asn221Asp (c.661 A > G) variants have been independently associated with metabolic pathways, including fatty acid oxidation and hormone processing, as well as a modestly increased risk of obesity. Clinical and genetic characterization of two patients with severe early-onset obesity revealed the co-occurrence of these variants, which were associated with metabolic disturbances such as insulin resistance. PURPOSE OF THE REVIEW: This narrative review examined the functional and clinical significance of UCP3 and PCSK1 variants in severe obesity, presenting two case reports to illustrate their potential impact. Our findings support a potential model in which rare variants in distinct metabolic genes may interact synergistically to exacerbate disease severity. Further studies are needed to elucidate their combined functional effects and contributions to obesity pathogenesis.

Indexed as

Obesity, MorbidProprotein Convertase 1Uncoupling Protein 3AdultFemaleGenetic Predisposition to DiseaseHumansInsulin ResistanceMalePCSK1 protein, humanProprotein Convertase 1UCP3 protein, humanUncoupling Protein 3

Identifiers

PMID40281302
PMCPMC12031958

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.