Trial reportClinical oral investigations2025
Adjunctive low-level laser therapy in periodontal treatment - A randomized clinical split-mouth trial.
Trial report in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Type of study: original study.Lasers in medical science · 2025Trial
- Low-Level Laser Therapy for Gingival Inflammation in Children and Adolescents: A Narrative Review Based on In Vitro, In Vivo and Clinical Studies.Healthcare (Basel, Switzerland) · 2026Review
- Causal digital twin modeling of periodontal healing: personalized prediction of low-level laser therapy benefit using a tooth-graph ODE transformer.Frontiers in dental medicine · 2026Article
- Recent Advances in Regenerative Therapies in Periodontology.Dentistry journal · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow-level laser therapy (LLLT) has been shown to exert biostimulatory effects, including increased cell proliferation and accelerated wound healing. Hence, the use of LLLT as an adjunct to scaling and root planing (SRP) for improved periodontal treatment outcomes has been examined. The aim of this study was to evaluate the clinical effect of adjunctive LLLT in the treatment of periodontitis with a 980-nm diode laser. MATERIALS AND
methodsPatients with a periodontal screening index of 3 or 4 who met the inclusion criteria were recruited and randomized into two groups for treatment allocation in a split-mouth design. The maxillary and mandibular left or right quadrants of the patients were assigned to either the test (SRP + LLLT) or the control (SRP) group. During the two final debridement sessions, LLLT was applied on one side of each study participant´s upper and lower jaws. The reevaluation of the clinical parameters and microbiological assays was performed 12 weeks after the initial therapy.
resultsBoth groups presented significant reductions in clinical parameters (p < 0.001). However, no statistically significant differences between the test and control groups were found for any of the parameters (all p values were greater than 0.05). The recolonization of P. gingivalis and T. denticola was not significantly reduced in the laser group.
conclusionThe clinical parameters in both groups improved similarly after initial periodontal treatment. LLLT with the chosen settings did not show a beneficial effect during the initial nonsurgical treatment of periodontitis. CLINICAL RELEVANCE: LLLT is under discussion for periodontal therapy as a promising treatment modality. Compared with nonsurgical therapy alone, adjunctive periodontal treatment with a diode laser did not improve the clinical parameters of periodontitis patients in this study. Currently, there is no recommended treatment protocol for adjunctive LLLT in periodontitis, which needs to be further investigated with other laser settings. CLINICAL
trial registrationISRCTN registry (#ISRCTN11275257), retrospectively registered, 16.10.2023.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.