SynthesisLipids in health and disease2025
The causal relationship between 179 lipid species and urolithiasis: a bidirectional and multivariable Mendelian randomization study combined with meta-analysis.
Synthesis in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Causal Links Between the Plasma Lipidome and Cognitive Performance: Targets, Pathways, and Lifestyle Influences.Molecular neurobiology · 2026Article
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6 authors.
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Abstract
backgroundPrevious research has suggested a potential link between urolithiasis and lipid species levels. A Mendelian randomization (MR) study was conducted to investigate whether a causal relationship exists between genetic susceptibility to plasma lipids and the risk of urolithiasis.
methodsData on lipid species were collected from genome-wide association (GWAS) analyses of plasma lipidomes. For the initial analysis, GWAS data on urolithiasis were extracted using the GWAS ID ebi-a-GCST90018935. The inverse variance weighted (IVW) approach was utilized as the main method for MR analysis. Multivariable MR, multiple supplementary analyses, and comprehensive sensitivity analyses were also conducted. Additional independent datasets were utilized for replication analysis and meta-analysis.
resultsFindings from the IVW method, repeated analyses, and meta-analysis revealed six significant causal effects of lipid species on urolithiasis. The specific lipid species identified were: phosphatidylcholine (PC; 16:1_20:4) levels [OR: 0.92; 95%CI: 0.87, 0.96; P = 6 × 10
conclusionThe MR study proposes a potential causal link between six plasma lipids and urolithiasis. Particularly, SEs (27:1/20:4), PC (16:0_20:4), and PC (16:1_20:4) may serve as potential inhibitors of calcium-containing urolithiasis growth. The integration of genomics and lipidomics in MR analysis holds promise for early screening, prevention, and treatment of urinary tract stones.
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