Evidence mapPaperPMID 40282437Full record

ReviewCancers2025

Oral Cancer and Sleep Disturbances: A Narrative Review on Exploring the Bidirectional Relationship.

Runhua Yang, Hongyu Jin, Chenyu Zhao, Wei Wang, Wen-Yang Li

Abstract readReview
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Runhua YangRespiratory and Critical Care Department, The First Hospital of China Medical University, Shenyang 110001, China.
Hongyu JinRespiratory and Critical Care Department, The First Hospital of China Medical University, Shenyang 110001, China.
Chenyu ZhaoDepartment of China Medical University-The Queen's University of Belfast Joint College, School of Pharmacy, China Medical University, Shenyang 110052, China.
Wei WangRespiratory and Critical Care Department, The First Hospital of China Medical University, Shenyang 110001, China.
Wen-Yang LiRespiratory and Critical Care Department, The First Hospital of China Medical University, Shenyang 110001, China.ORCID 0000-0002-2792-4217

Funding

the National Natural Science Foundation of China No.82370093
6 · The paper itself

Abstract

Oral cancer is a common malignant tumor, and its incidence has steadily increased in recent years. Sleep disturbances, including insomnia and obstructive sleep apnea, are prevalent among patients with oral cancer and significantly impact their quality of life. Emerging research suggests a bidirectional relationship between oral cancer and sleep disorders. This article reviews how oral cancer induces or exacerbates sleep disorders, particularly obstructive sleep apnea (OSA), through factors such as pain, psychological stress, and treatment-related side effects (e.g., upper airway damage caused by chemotherapy, radiotherapy, or surgical interventions). Furthermore, it analyzes how sleep disorders may promote oral cancer progression via chronic inflammation, intermittent hypoxia, oxidative stress, and disruption of circadian rhythms. By elucidating these interactions, this review provides a theoretical foundation for optimizing clinical treatment plans through a holistic understanding of their shared pathophysiological mechanisms.

Indexed as

bidirectional relationshipdisruption of circadian rhythmsintermittent hypoxiaobstructive sleep apneaoral cancersleep disturbances

Identifiers

PMID40282437
PMCPMC12025584

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.