Evidence map›Paper›PMID 40284259›Full record

ArticleNutrients2025

The Relationship between Visceral Fat Accumulation and Risk of Cardiometabolic Multimorbidity: The Roles of Accelerated Biological Aging.

Tianyu Zhu, Yixing Tian, Jinqi Wang, Zhiyuan Wu, Wenhan Xie, Haotian Liu, Xia Li, Lixin Tao, Xiuhua Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tianyu ZhuBeijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, No. 10 Xitoutiao, Youanmen Street, Beijing 100069, China.
Yixing TianBeijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, No. 10 Xitoutiao, Youanmen Street, Beijing 100069, China.ORCID 0009-0000-4717-7784
Jinqi WangBeijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, No. 10 Xitoutiao, Youanmen Street, Beijing 100069, China.
Zhiyuan WuDepartment of Nutrition, Harvard T.H. Chan School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA.
Wenhan XieBeijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, No. 10 Xitoutiao, Youanmen Street, Beijing 100069, China.
Haotian LiuBeijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, No. 10 Xitoutiao, Youanmen Street, Beijing 100069, China.
Xia LiDepartment of Mathematics and Statistics, La Trobe University, Melbourne, VIC 3086, Australia.
Lixin TaoBeijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, No. 10 Xitoutiao, Youanmen Street, Beijing 100069, China.ORCID 0000-0002-2135-046X
Xiuhua GuoBeijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, No. 10 Xitoutiao, Youanmen Street, Beijing 100069, China.ORCID 0000-0001-6657-6940

Funding

National Natural Science Foundation of China 82373683
6 · The paper itself

Abstract

objectivesTo investigate the association between visceral fat accumulation and the risk of cardiometabolic multimorbidity (CMM) and the potential roles of accelerated biological aging in this relationship.

methodsUsing data from the UK Biobank, a nationwide cohort study was conducted using the available baseline body roundness index (BRI) measurement. Biological aging was assessed using the Klemera-Doubal method for biological age and the phenotypic age algorithms. The association between the BRI and CMM was estimated using the Cox proportional hazards regression model, while the roles of biological aging were examined through interaction and mediation analyses.

resultsDuring a median follow-up of 14.52 years, 6156 cases of CMM were identified. A significant association was observed between the BRI and CMM. The hazard ratio (HR) for CMM was 3.72 (95% confidence interval [CI]: 3.35-4.13) for individuals in the highest quartile compared with those in the lowest quartile of the BRI. More importantly, the BRI (AUC, 0.701; 95% CI, 0.694-0.707) demonstrated superior predictive performance relative to body mass index (AUC, 0.657; 95% CI, 0.650-0.664). Furthermore, the BRI exhibited additive interactions with accelerated biological aging on the risk of CMM, and accelerated biological aging partially mediated the association between the BRI and CMM.

conclusionsThese findings provide evidence for the application of the BRI as a novel and readily accessible screening tool associated with CMM, suggesting that the effective management of visceral fat and biological aging deceleration may hold promise for reducing CMM risk.

Indexed as

AgingCardiovascular DiseasesIntra-Abdominal FatMultimorbidityAdultAgedBody Mass IndexCardiometabolic Risk FactorsCohort StudiesFemaleHumansMaleMiddle AgedProportional Hazards ModelsRisk FactorsUnited Kingdomaccelerated biological agingbody roundness indexcardiometabolic multimorbidityvisceral obesity

Identifiers

PMID40284259
PMCPMC12030224

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.