Evidence map›Paper›PMID 40284479›Full record

ArticlePharmaceutics2025

Safety Profile, Toxicokinetic, and Intestinal Absorption Differences of a Naturally-Derived Anti-Rheumatic Drug, Sinomenine Hydrochloride, in Normal and Arthritic Rats.

Yini He, Hong Huang, Gejing Li, Ye Zhang, Junjie He, Ye Lin, Feichi Wu, Jianye Yan, Xiong Cai, Liang Liu

Abstract read
In one paragraph

Article in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yini HeInstitute of Innovation and Applied Research in Chinese Medicine, School of Chinese Medical Sciences, Hunan University of Chinese Medicine, Changsha 410208, China.
Hong HuangInstitute of Innovation and Applied Research in Chinese Medicine, School of Chinese Medical Sciences, Hunan University of Chinese Medicine, Changsha 410208, China.
Gejing LiInstitute of Innovation and Applied Research in Chinese Medicine, School of Chinese Medical Sciences, Hunan University of Chinese Medicine, Changsha 410208, China.
Ye ZhangInstitute of Innovation and Applied Research in Chinese Medicine, School of Chinese Medical Sciences, Hunan University of Chinese Medicine, Changsha 410208, China.
Junjie HeInstitute of Innovation and Applied Research in Chinese Medicine, School of Chinese Medical Sciences, Hunan University of Chinese Medicine, Changsha 410208, China.
Ye LinInstitute of Innovation and Applied Research in Chinese Medicine, School of Chinese Medical Sciences, Hunan University of Chinese Medicine, Changsha 410208, China.
Feichi WuHunan ZhenQin Pharmaceutical Group Co., Ltd., Huaihua 418000, China.
Jianye YanInstitute of Innovation and Applied Research in Chinese Medicine, School of Chinese Medical Sciences, Hunan University of Chinese Medicine, Changsha 410208, China.
Xiong CaiInstitute of Innovation and Applied Research in Chinese Medicine, School of Chinese Medical Sciences, Hunan University of Chinese Medicine, Changsha 410208, China.ORCID 0000-0003-4644-4451
Liang LiuState Key Laboratory of Traditional Chinese Medicine Syndrome, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China.

Funding

121 Training Project for Innovative Talents of Hunan XRSH[2019]192China Postdoctoral Science Foundation 2022M721128China Postdoctoral Science Foundation 2024T170267Chinese Academy of Engineering Academician Liang Liu's Workstation KH[2023]3-23YS001Furong Distinguished Scholar Program of Hunan XJT[2020]58National Natural Science Foundation of China General Program 82274506National Natural Science Foundation of China General Program 82405235Natural Science Foundation of Hunan 2023JJ40477Natural Science Foundation of Hunan 2024JJ5298Open-competing Disciple Construction Project of Hunan University of Chinese Medicine (HNUCM) 22JBZ003Science and Technology Innovation Program of Hunan Province 2020SK1020Science and Technology Innovation Program of Hunan Province 2021RC4035World First-class Discipline Incubation Project of HNUCM XJF[2022]57
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

adjuvant-induced arthritisintestinal absorptionP–glycoproteinsafety profilesinomenine hydrochloridetoxicokinetic

Identifiers

PMID40284479
PMCPMC12030057

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.