Evidence map›Paper›PMID 40284579›Full record

ReviewMicroorganisms2025

Industrial Microbial Technologies for Feed Protein Production from Non-Protein Nitrogen.

Yuxin Ye, Yafan Cai, Fei Wang, Yi He, Yuxuan Yang, Zhengxiang Guo, Mengyu Liu, Huimin Ren, Shilei Wang, Dong Liu and 2 more

Abstract readReview
In one paragraph

Review in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuxin YeSchool of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, China.
Yafan CaiSchool of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, China.ORCID 0000-0003-1624-1346
Fei WangSchool of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, China.
Yi HeSchool of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, China.
Yuxuan YangSchool of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, China.
Zhengxiang GuoSchool of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, China.
Mengyu LiuSchool of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, China.
Huimin RenSchool of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, China.
Shilei WangSchool of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, China.
Dong LiuCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China.ORCID 0000-0002-3009-7590
Jingliang XuSchool of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, China.
Zhi WangSchool of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, China.ORCID 0000-0001-7081-2854

Funding

the National Natural Science Foundation of China 22308338the National Natural Science Foundation of China 52200178
6 · The paper itself

Abstract

Due to the increasing global demand for feed protein, microbial protein has great potential of being able to feed sustainably. However, the application of microbial protein in the animal cultivation industry is still limited by its high cost and availability on scale. From the viewpoint of industrial production, it is vital to specify the crucial processes and components for further technical exploration and process optimization. This article presents state-of-the-art industrial microbial technologies for non-protein nitrogen (NPN) assimilation in feed protein production. Nitrogen sources are one of the main cost factors in the media used for large-scale microbial protein fermentation. Therefore, the available NPN sources for microbial protein synthesis, NPN utilization mechanisms, and fermentation technologies corresponding to the strain and NPN are reviewed in this paper. Especially, the random mutagenesis and adaptive laboratory evolution (ALE) approach combined with (ultra-) throughput screening provided the main impetus for strain evolution to increase the protein yield. Despite the underlying potential and technological advances in the production of microbial protein, extensive research and development efforts are still required before large-scale commercial application of microbial protein in animal feed.

Indexed as

adaptive laboratory evolutionfeed proteinindustrial microbiologymicrobial proteinnon-protein nitrogen

Identifiers

PMID40284579
PMCPMC12029832

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.