Evidence map›Paper›PMID 40284897›Full record

ArticleViruses2025

Chronic Hepatitis B in the Transplant Setting: A 30-Year Experience in a Single Tertiary Italian Center.

Francesco Paolo Russo, Sara Battistella, Alberto Zanetto, Martina Gambato, Alberto Ferrarese, Giacomo Germani, Marco Senzolo, Claudia Mescoli, Salvatore Piano, Francesco Enrico D'Amico and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Francesco Paolo RussoGastroenterology and Multivisceral Transplant Unit, Azienda Ospedale-Università di Padova, 35125 Padua, Italy.ORCID 0000-0003-4127-8941
Sara BattistellaGastroenterology and Multivisceral Transplant Unit, Azienda Ospedale-Università di Padova, 35125 Padua, Italy.ORCID 0009-0002-0326-7088
Alberto ZanettoGastroenterology and Multivisceral Transplant Unit, Azienda Ospedale-Università di Padova, 35125 Padua, Italy.ORCID 0000-0002-6734-7178
Martina GambatoGastroenterology and Multivisceral Transplant Unit, Azienda Ospedale-Università di Padova, 35125 Padua, Italy.ORCID 0000-0002-0101-1938
Alberto FerrareseGastroenterology and Multivisceral Transplant Unit, Azienda Ospedale-Università di Padova, 35125 Padua, Italy.ORCID 0000-0002-3248-2038
Giacomo GermaniGastroenterology and Multivisceral Transplant Unit, Azienda Ospedale-Università di Padova, 35125 Padua, Italy.
Marco SenzoloGastroenterology and Multivisceral Transplant Unit, Azienda Ospedale-Università di Padova, 35125 Padua, Italy.
Claudia MescoliDepartment of Medicine, (Pathology Section), University Hospital of Padua, 35125 Padua, Italy.
Salvatore PianoUnit of Internal Medicine and Hepatology, Department of Medicine, University of Padua, 35125 Padua, Italy.
Francesco Enrico D'AmicoDepartment of Surgery, Oncology and Gastroenterology, University of Padua, 35125 Padua, Italy.ORCID 0000-0002-3114-8521
Alessandro VitaleDepartment of Surgery, Oncology and Gastroenterology, University of Padua, 35125 Padua, Italy.ORCID 0000-0002-4548-8308
Enrico GringeriDepartment of Surgery, Oncology and Gastroenterology, University of Padua, 35125 Padua, Italy.ORCID 0000-0002-3459-7306
Paolo FeltraccoAnaesthesia and Intensive Care, Department of Medicine, Padua University Hospital, 35125 Padua, Italy.
Paolo AngeliUnit of Internal Medicine and Hepatology, Department of Medicine, University of Padua, 35125 Padua, Italy.
Umberto CilloDepartment of Surgery, Oncology and Gastroenterology, University of Padua, 35125 Padua, Italy.ORCID 0000-0002-2310-0245
Patrizia BurraGastroenterology and Multivisceral Transplant Unit, Azienda Ospedale-Università di Padova, 35125 Padua, Italy.ORCID 0000-0002-8791-191X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatitis B virus (HBV) remains a leading etiology for liver transplantation (LT). In a large cohort of HBsAg-positive patients, this study evaluates long-term patient and graft survival after LT over the past 30 years while analyzing trends and outcomes following waiting list (WL) inclusion over the last 15 years.

methodsHBsAg-positive patients who underwent transplantation between 1991 and 2020 and were waitlisted from 2006 to 2020 at Padua Hospital were included in the analysis. Patients were stratified according to hepatitis delta virus (HDV) coinfection, transplant indication (decompensated cirrhosis vs. hepatocellular carcinoma (HCC)), and WL inclusion period.

resultsAmong 321 HBsAg-positive LT recipients (31.5% HDV-coinfected, 46.4% HCC), 1-year and 5-year patient/graft survival rates were 87.6%/86.7% and 82.6%/82.2%, respectively. From 2006 to 2020, 284 HBsAg-positive patients were waitlisted (32.6% HDV-coinfected), with a significantly higher prevalence of HCC compared to non-HBV patients (

conclusionsOver the past 30 years, HBV has remained a consistent indication for LT at our center. Thanks to hbNUCs, WL outcomes have improved and HCC has become the main indication for LT.

Indexed as

Hepatitis B, ChronicLiver TransplantationAdultAgedCarcinoma, HepatocellularCoinfectionFemaleGraft SurvivalHepatitis B Surface AntigensHepatitis B virusHepatitis DHepatitis Delta VirusHumansItalyLiver CirrhosisLiver NeoplasmsHepatitis B Surface AntigensHBIGHBVHBV prophylaxisHDVliver transplantationNUCs

Identifiers

PMID40284897
PMCPMC12030929

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.