Evidence map›Paper›PMID 40284905›Full record

ArticleViruses2025

Chronic Hepatitis B Virus Infection and HLA Variations in a Greek Population.

Evangelia Myserli, Ioannis Goulis, Asimina Fylaktou, Maria Exindari, Fani Minti, Georgia Chatzika, Eleni Iliopoulou, Polyxeni Agorastou, Ioanna Papagiouvanni, Theodora Oikonomou and 1 more

Abstract read
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In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Evangelia MyserliMicrobiology Department, Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Ioannis GoulisFourth Department of Internal Medicine, Hippokration General Hospital, 54642 Thessaloniki, Greece.
Asimina FylaktouNational Peripheral Histocompatibility Center, Immunology Department, Hippokration General Hospital, 54642 Thessaloniki, Greece.
Maria ExindariMicrobiology Department, Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0002-4052-8550
Fani MintiMicrobiology Department, Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Georgia ChatzikaNational Peripheral Histocompatibility Center, Immunology Department, Hippokration General Hospital, 54642 Thessaloniki, Greece.
Eleni IliopoulouNational Peripheral Histocompatibility Center, Immunology Department, Hippokration General Hospital, 54642 Thessaloniki, Greece.
Polyxeni AgorastouFourth Department of Internal Medicine, Hippokration General Hospital, 54642 Thessaloniki, Greece.
Ioanna PapagiouvanniFourth Department of Internal Medicine, Hippokration General Hospital, 54642 Thessaloniki, Greece.ORCID 0000-0001-5190-0154
Theodora OikonomouFourth Department of Internal Medicine, Hippokration General Hospital, 54642 Thessaloniki, Greece.ORCID 0000-0002-9077-4960
Georgia GioulaMicrobiology Department, Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic hepatitis B is linked with considerable liver-related morbidity and mortality globally. Human leukocyte antigen (HLA) polymorphisms affect the susceptibility and outcome of many immune-mediated diseases and infections. Our aim was to study the impact of HLA alleles on HVB-infected individuals in a Greek population. In total, 107 patients with chronic HBV infection (cHBV group) and 101 with spontaneous clearance (SC-group) of hepatitis B surface antigen (HBsAg) were genotyped for HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci by single-specific primer polymerase chain reaction (PCR-SSP). The HLA alleles' frequencies were compared between the two patient groups and healthy individuals from the North Greece Bone Marrow Donor Registry (14506 samples). We found a significantly increased frequency of HLA-C*01 and HLA-DRB1*16 alleles in the cHBV group versus the SC-group. The frequency of HLA-A*01, HLA-B*08, HLA-C*01, HLA-C*08, HLA-DRB1*03, and HLA-DQB1*05 alleles was significantly higher in cHBV patients versus healthy individuals, while the frequency of the HLA-B*38 allele was significantly lower. Our study showed an association of specific HLA alleles with either susceptibility or protection against chronic HBV infection.

Indexed as

Hepatitis B, ChronicHLA AntigensAdultAgedAllelesFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeGreeceHepatitis B virusHumansMaleMiddle AgedPolymorphism, GeneticYoung AdultHLA Antigenschronic HBV infectionHBV clearanceHBV virusHLA class I allelesHLA class II alleles

Identifiers

PMID40284905
PMCPMC12031174

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.