Evidence map›Paper›PMID 40284913›Full record

ArticleViruses2025

HTLV-1 p13 Protein Hijacks Macrophage Polarization and Promotes T-Cell Recruitment.

Ramona Moles, Maria Omsland, Cynthia A Pise-Masison, Jeffrey J Subleski, Daniel W McVicar, Sarkis Sarkis, Anna Gutowska, Luca Schifanella, Melvin Doster, Robyn Washington-Parks and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Macrophages in oncoviral infections: from immune regulators to therapeutic targets.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ramona MolesAnimal Models and Retroviral Vaccines Section, Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Maria OmslandAnimal Models and Retroviral Vaccines Section, Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-0818-6490
Cynthia A Pise-MasisonAnimal Models and Retroviral Vaccines Section, Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Jeffrey J SubleskiCancer and Innovation Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Daniel W McVicarCancer and Innovation Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.ORCID 0000-0002-1112-5111
Sarkis SarkisAnimal Models and Retroviral Vaccines Section, Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Anna GutowskaAnimal Models and Retroviral Vaccines Section, Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-9873-6432
Luca SchifanellaAnimal Models and Retroviral Vaccines Section, Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Melvin DosterAnimal Models and Retroviral Vaccines Section, Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Robyn Washington-ParksAnimal Models and Retroviral Vaccines Section, Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Vincenzo CiminaleDepartment of Surgery, Oncology and Gastroenterology, University of Padua, 35122 Padua, Italy.
Genoveffa FranchiniAnimal Models and Retroviral Vaccines Section, Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-2851-6589

Funding

Sex differences in operant cocaine memoriesP20GM144041 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Ramona Moles · 2023 to 2026
$12.1M
Italian Association for Cancer Research 24935NIGMS NIH HHS P20 GM144041NIH HHS n/a
6 · The paper itself

Abstract

The human T-cell leukemia type-1 (HTLV-1) retrovirus establishes chronic life-long infection in a fraction of infected individuals associated with severe pathological conditions. Although the mechanism driving disease development is not fully understood, current evidence indicates the essential functions of viral regulatory proteins. Among these, the p13 protein has previously been shown to localize to the inner mitochondrial membrane in T cells, altering mitochondrial biology and T-cell function. While CD4

Indexed as

CD4-Positive T-LymphocytesHTLV-I InfectionsHuman T-lymphotropic virus 1MacrophagesHumansMitochondriaMonocytesadult-T-cell leukemia/lymphomaATLLcytokinesHAM/TSPHTLV-1HTLV-1 associated myelopathy/tropical spastic paraparesismacrophagesmitochondriamonocytesp13viral protein

Identifiers

PMID40284913
PMCPMC12031607

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.