ArticleEuropean archives of psychiatry and clinical neuroscience2025
Associations between suicidal ideation and childhood maltreatment as well as inflammatory cytokines in adolescents with major depressive disorder.
Article in European archives of psychiatry and clinical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Advancing the understanding of psychosis: integrating trauma, substance use, and neurobiological evidence.European archives of psychiatry and clinical neuroscience · 2026Article
- Thyroid-stimulating hormone, fasting blood glucose and suicidal ideation in Chinese adolescents with major depressive disorder: a cross-sectional study.Frontiers in psychiatry · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundSuicidal ideation (SI) is thought to be associated with childhood maltreatment (CM) and inflammatory processes. Yet, these links are not thoroughly studied in adolescents with major depressive disorder (MDD). So, this study focused on investigating the predictive value of CM and inflammatory cytokines for SI in this population.
methodsThis study included 156 depressed adolescents. The Center for Epidemiological Studies Depression Scale (CES-D), the Childhood Trauma Questionnaire (CTQ) and the Positive and Negative Suicidal Ideation Scale (PANSI) were used to assess depression, CM and SI, respectively. Additionally, plasma inflammatory cytokines levels were measured, including interleukin (IL)-1β, IL-6, IL-10, IL-17A and tumor necrosis factor-α (TNF-α).
resultsUnivariate analyses showed that females had higher levels of SI in adolescents with MDD. Moreover, the level of SI was negatively correlated with age and age at onset, and positively correlated with duration of illness, CES-D score, CTQ score, as well as levels of IL-1β, IL-6 and TNF-α (all p < 0.05). Furthermore, regression analyses revealed that SI was independently associated with age at onset, CES-D score, CTQ score, and Log IL-1β (all p < 0.05). Finally, receiver operating characteristic (ROC) curve analyses revealed that the combination of the CES-D score, CTQ score, and IL-1β (AUC = 0.910, 95% CI = 0.864-0.956, p < 0.001) had a better ability to identify SI in adolescents with MDD, exhibiting higher sensitivity and specificity.
conclusionSI is associated with depressive symptoms, CM and elevated levels of inflammatory cytokines (especially IL-1β) in adolescents with MDD. In the future, interventions such as cognitive behavioural therapy and the administration of anti-inflammatory drugs, targeting the modulation of CM and inflammatory cytokine levels, may play important roles in preventing suicidal behaviors in depressed adolescents.
Indexed as
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40285829What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.