Evidence map›Paper›PMID 40285939›Full record

ReviewMolecular neurobiology2025

The Cooperation of Neurogranin with Calmodulin Promotes the Treatment of Aging-Related Diseases via Regular Exercise.

Hosniyeh Rajavand, Vahideh Zalouli, Zeinab Nematollahi, Farshid Fathy-Karkaragh, Elham Karimigharighi, Farzad Jafarizadeh, Amirhossein Rabiei Rad

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hosniyeh RajavandRegenerative Medicine Group (REMED), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Vahideh ZalouliRegenerative Medicine Group (REMED), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Zeinab Nematollahi4UCL Department of Nanotechnology, Division of Surgery and Interventional Science, University College London, London, UK.
Farshid Fathy-KarkaraghDepartment of Psychology, Faculty of Educational Sciences and Psychology, University of Tehran, Tehran, Iran.
Elham KarimigharighiDiagnostic Radiology and Nuclear Medicine, University of Maryland Baltimore, Baltimore, MD, USA.
Farzad JafarizadehRegenerative Medicine Group (REMED), Universal Scientific Education and Research Network (USERN), Tehran, Iran. farzadjafarizadeh7@gmail.com.
Amirhossein Rabiei RadDepartment of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Tokat Gaziosmanpaşa University, Tokat, Turkey. Rabieirad.amirhossein@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Research has demonstrated that engaging in regular exercise has the potential to enhance cognitive function, promote neuroplasticity, and mitigate the likelihood of experiencing cognitive decline. The underlying mechanisms responsible for these effects are intricate and encompass various pathways, including the interaction between neurogranin and calmodulin. The activation of calcium signaling pathways is a significant mechanism through which regular exercise facilitates the treatment of age-related diseases. The activation of neurogranin and calmodulin induced by exercise can provide protection against neurodegeneration by promoting neuronal survival, mitigating oxidative stress, and improving mitochondrial function through the regulation of calcium homeostasis and energy metabolism. In addition, there is evidence suggesting that engaging in regular exercise can lead to an upregulation of neurotrophic factors, specifically brain-derived neurotrophic factor (BDNF). These factors are crucial for the survival of neurons, the plasticity of synapses, and overall cognitive function. Researchers have discovered the involvement of neurogranin in the regulation of BDNF signaling, underscoring its significance in exercise-induced neuroprotection and cognitive enhancement. The current work offers valuable insights into how neurogranin/calmodulin cooperation, facilitated by regular exercise, promotes the treatment of aging-related diseases. The results suggest that regular exercise could enhance memory, learning, synaptic plasticity, and resilience to neurological damage; promote recovery after brain injury; and treat aging-related disorders such as Alzheimer's disease.

Indexed as

AgingCalmodulinExerciseNeurograninAnimalsBrain-Derived Neurotrophic FactorHumansNeuronal PlasticityBrain-Derived Neurotrophic FactorCalmodulinNeurograninAging-related diseasesAlzheimer’s diseaseCalmodulinNeurograninRegular exercise

Identifiers

PMID40285939

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.