Decarboxylation-Driven Double Annulations: Innovative Multi-Component Reaction Pathways.

Desheng Zhan, Gang Yang, Tieli Zhou, Sashirekha Nallapati, Xiaofeng Zhang

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Recent Developments in Azomethine Ylide-Initiated Double Cycloadditions.Molecules (Basel, Switzerland) · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Desheng ZhanCollege of Chemistry, Changchun Normal University, Changchun 130032, China.

Gang YangCollege of Food Science and Engineering, Changchun University, Changchun 130022, China.

Tieli ZhouCollege of Food Science and Engineering, Changchun University, Changchun 130022, China.

Sashirekha NallapatiDepartment of Chemistry & Chemical Biology, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA.

Xiaofeng ZhangDepartment of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Harvard University, Boston, MA 02215, USA.ORCID 0000-0003-4529-1158

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A concerted five-component reaction strategy has been developed, featuring double [3+2] cycloadditions utilizing aspartic acid. This approach provides valuable insights into mechanistic pathways, allowing for the distinction between concerted and stepwise processes based on reaction efficiency and diastereoselectivity. Both aspartic and glutamic acids have been employed for a thorough evaluation and exploration of decarboxylation-driven double annulations. This method effectively constructs pyrrolizidine frameworks through a concerted double 1,3-dipolar cycloaddition with aspartic acid, as well as tetrahydropyrrolizinones via three-component double annulations, which include decarboxylative 1,3-dipolar cycloaddition and lactamization with glutamic acid. These highly convergent, decarboxylation-driven multicomponent reactions (MCRs) efficiently produce fused polyheterocyclic systems while being environmentally friendly, generating only CO

Indexed as

annulationsazomethine ylidesconverted reactionscycloadditiondecarboxylationmulticomponent reactions

Identifiers

PMID40286179

DOI10.3390/molecules30071594

PMCPMC11990421

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.