Evidence map›Paper›PMID 40286213›Full record

ArticleMolecules (Basel, Switzerland)2025

Inhibition of Tyrosinase and Melanogenesis by Carboxylic Acids: Mechanistic Insights and Safety Evaluation.

Yu-Pei Chen, Mingyu Li, Zirong Liu, Jinxiong Wu, Fangfang Chen, Shudi Zhang

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yu-Pei ChenThe School of Public Health, Fujian Medical University, Fuzhou 350122, China.ORCID 0000-0001-9108-5756
Mingyu LiThe School of Public Health, Fujian Medical University, Fuzhou 350122, China.
Zirong LiuThe School of Public Health and Medical Technology, Xiamen Medical College, Xiamen 361023, China.
Jinxiong WuThe School of Public Health and Medical Technology, Xiamen Medical College, Xiamen 361023, China.
Fangfang ChenThe School of Public Health and Medical Technology, Xiamen Medical College, Xiamen 361023, China.
Shudi ZhangThe School of Public Health and Medical Technology, Xiamen Medical College, Xiamen 361023, China.ORCID 0000-0003-2055-8821

Funding

General Project of Natural Science Foundation by the Science and Technology Bureau of Xiamen, Xiamen, Fujian, China 3502Z20227224General Project of Xiamen Medical College, Xiamen, Fujian, China K2021-07
6 · The paper itself

Abstract

It is well established that certain carboxylic acid compounds can effectively inhibit tyrosinase activity. This study investigated the mechanisms by which four carboxylic acid compounds-3-phenyllactic acid, lactic acid, L-pyroglutamic acid, and malic acid-inhibit tyrosinase and melanogenesis. IC

Indexed as

Carboxylic AcidsEnzyme InhibitorsMelaninsMonophenol MonooxygenaseAgaricalesAnimalsKineticsMalatesMelanogenesisMiceCarboxylic AcidsEnzyme InhibitorsMalatesmalic acidMelaninsMonophenol Monooxygenase3-phenyllactic acidcarboxylic acidDOPA auto-oxidationL-pyroglutamic acidmelanintyrosinase

Identifiers

PMID40286213
PMCPMC11990924

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.