Evidence map›Paper›PMID 40287553›Full record

ReviewMolecular psychiatry2025

Brain circuits that regulate social behavior.

Hao Li, Zhe Zhao, Shaofei Jiang, Haitao Wu

Abstract readReview
In one paragraph

Review in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. Review
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  16. Negative allosteric modulation of α5-GABAbioRxiv : the preprint server for biology · 2026
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  17. Review
  18. Review
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  20. Distinct neural dynamics in the ventral hippocampus and medial prefrontal cortex during social information processing.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hao Li *Department of Neurobiology, Beijing Institute of Basic Medical Sciences, Beijing, 100850, China.
Zhe Zhao *Department of Neurobiology, Beijing Institute of Basic Medical Sciences, Beijing, 100850, China.
Shaofei Jiang *Department of Neurobiology, Beijing Institute of Basic Medical Sciences, Beijing, 100850, China.
Haitao WuDepartment of Neurobiology, Beijing Institute of Basic Medical Sciences, Beijing, 100850, China. wuht@bmi.ac.cn.ORCID http://orcid.org/0000-0001-8437-3194

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32171148
6 · The paper itself

Abstract

Social interactions are essential for the survival of individuals and the reproduction of populations. Social stressors, such as social defeat and isolation, can lead to emotional disorders and cognitive impairments. Furthermore, dysfunctional social behaviors are hallmark symptoms of various neuropsychiatric disorders, including autism spectrum disorder (ASD) and post-traumatic stress disorder (PTSD). Consequently, understanding the neural circuit mechanisms underlying social behaviors has become a major focus in neuroscience. Social behaviors, which encompass a wide range of expressions and phases, are regulated by complex neural networks. In this review, we summarize recent progress in identifying the circuits involved in different types of social behaviors, including general social investigation, social preference, mating, aggression, parenting, prosocial behaviors, and dominance behaviors. We also outline the circuit mechanisms associated with social deficits in neuropsychiatric disorders, such as ASD, schizophrenia, and PTSD. Given the pivotal role of rodents in social behavior research, our review primarily focuses on neural circuits in these animals. Finally, we propose future research directions, including the development of specific behavioral paradigms, the identification of circuits involved in motor output, the integration of activity, transcriptome, and connectome data, the multifunctional roles of neurons with multiple targets, and the interactions among multiple brain regions.

Indexed as

BrainSocial BehaviorAnimalsAutism Spectrum DisorderHumansNerve NetNeural PathwaysNeuronsSchizophreniaStress Disorders, Post-Traumatic

Identifiers

PMID40287553
PMCPMC12185352

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.