Evidence map›Paper›PMID 40287603›Full record

ArticleNPJ digital medicine2025

Dual stream transformer for medication state classification in Parkinson's disease patients using facial videos.

Vasileios Skaramagkas, Iro Boura, Georgios Karamanis, Ioannis Kyprakis, Dimitrios I Fotiadis, Zinovia Kefalopoulou, Cleanthe Spanaki, Manolis Tsiknakis

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Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vasileios SkaramagkasElectrical and Computer Engineering, Hellenic Mediterranean University, Estavromenos, Heraklion, GR-710 04, Greece. vskaramagkas96@gmail.com.
Iro BouraSchool of Medicine, University of Crete, A. Kalokerinou 13, Heraklion, GR-715 00, Greece.
Georgios KaramanisDepartment of Neurology, Patras University Hospital, Rion, Patras, GR-264 04, Greece.
Ioannis KyprakisElectrical and Computer Engineering, Hellenic Mediterranean University, Estavromenos, Heraklion, GR-710 04, Greece.
Dimitrios I FotiadisUnit of Medical Technology and Intelligent Information Systems, University of Ioannina, Ioannina, GR-451 10, Greece.
Zinovia Kefalopoulou *Department of Neurology, Patras University Hospital, Rion, Patras, GR-264 04, Greece. zkefalopoulou@gmail.com.
Cleanthe Spanaki *School of Medicine, University of Crete, A. Kalokerinou 13, Heraklion, GR-715 00, Greece. kliospanaki@gmail.com.
Manolis Tsiknakis *Electrical and Computer Engineering, Hellenic Mediterranean University, Estavromenos, Heraklion, GR-710 04, Greece. tsiknaki@ics.forth.gr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypomimia is a prominent, levodopa-responsive symptom in Parkinson's disease (PD). In our study, we aimed to distinguish ON and OFF dopaminergic medication state in a cohort of PD patients, analyzing their facial videos with a unique, interpretable Dual Stream Transformer model. Our approach integrated two streams of data: facial frame features and optical flow, processed through a transformer-based architecture. Various configurations of embedding dimensions, dense layer sizes, and attention heads were examined to enhance model performance. The final model, trained on 183 PD patients, attained an accuracy of 86% in differentiating between ON- and OFF-medication state. Moreover, uniform classification performance (up to 88%) was obtained across various stages of PD severity, as expressed by the Hoehn and Yahr (H&Y) scale. These values highlight the potential of our model as a non-invasive, cost-effective instrument for clinicians to remotely and accurately detect patients' response to treatment from early to more advanced PD stages.

Identifiers

PMID40287603
PMCPMC12033283

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.