ArticlePain2025
Multimodal hypersensitivity and somatic symptoms predict adolescent postmenarchal widespread pain.
Article in Pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Auditory Hyperresponsivity in Chronic Back Pain: A Randomized Controlled Trial of Pain Reprocessing Therapy.Annals of neurology · 2026Trial
- Multi-Site Pain During Menstruation in Adolescents is Associated With Impaired Functioning Across Various Domains: A Cross-Sectional Observational Study.Journal of pediatric and adolescent gynecology · 2026Observational
- Acute effects of nitrous oxide on visual processing: a connectome study in healthy adults.Research square · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
abstractWidespread pain in adolescence is linked with poor mental health, pain, and somatic symptoms in childhood. This prospective study in 207 premenarchal adolescents used quantitative sensory testing (QST) and multimodal hypersensitivity (MMH) measures to assess somatosensory system function and identify predictors for widespread pain (≥3/7 sites). We hypothesized that premenarchal pain, somatic symptoms, psychological factors, and somatosensory system function would predict postmenarchal widespread pain, which would be associated with greater menstrual pain intensity. At premenarchal and postmenarchal study visits, participants completed measures of somatic symptoms, a pain body map, psychosocial questionnaires, QST, and experimental MMH measures including auditory, visual, and visceral stimulation. Electroencephalography (EEG) was collected during auditory and visual tasks to identify neural correlates of MMH. Premenarchal widespread pain was reported by 25% of participants, whereas 29% developed new incident widespread pain postmenarche. Adolescents with postmenarchal widespread pain reported greater menstrual pain intensity (median [interquartile range] 47 [28-61]; 0-100 visual analog scale) than those without (24 [8-50], P = 0.001). Elevated somatic symptoms ( P = 0.012), stress ( P = 0.015), and sensitivity to visceral (bladder filling) ( P = 0.046) and unpleasant visual stimuli ( P = 0.043) were significant predictors of postmenarche widespread pain. A multivariable regression model found premenarchal body map score (OR = 1.75, 95% CI [1.20, 2.55]), somatic symptoms (OR = 1.47, 95% CI [1.03, 2.11]), and visual hypersensitivity (OR = 1.62, 95% CI [1.12, 2.33]) predicted postmenarchal widespread pain. No EEG differences in early cortical sensory processing were found. Our results suggest that increased sensitivity to multimodal unpleasant and painful stimuli represents a novel risk factor for postmenarche widespread pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.