Evidence map›Paper›PMID 40289353›Full record

ArticleJournal of the American Chemical Society2025

Molybdenum Cofactor Model Reveals Remarkable Redox Activity at Both Molybdenum and the Pyranopterin Dithiolene Ligand.

Jinming Liu, Angelina Rogatch, Benjamin R Williams, Chelsea Freer, Chiara Zuccoli, Jing Yang, Martin L Kirk, Sharon J Nieter Burgmayer

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jinming LiuDepartment of Chemistry, Bryn Mawr College, Bryn Mawr, Pennsylvania 19010, United States.
Angelina RogatchDepartment of Chemistry, Bryn Mawr College, Bryn Mawr, Pennsylvania 19010, United States.
Benjamin R WilliamsDepartment of Chemistry, Bryn Mawr College, Bryn Mawr, Pennsylvania 19010, United States.
Chelsea FreerDepartment of Chemistry, Bryn Mawr College, Bryn Mawr, Pennsylvania 19010, United States.
Chiara ZuccoliDepartment of Chemistry, Bryn Mawr College, Bryn Mawr, Pennsylvania 19010, United States.
Jing YangDepartment of Chemistry and Chemical Biology, The University of New Mexico, MSC03 2060, 1 University of New Mexico, Albuquerque, New Mexico 87131-0001, United States.ORCID 0000-0001-8241-9160
Martin L KirkDepartment of Chemistry and Chemical Biology, The University of New Mexico, MSC03 2060, 1 University of New Mexico, Albuquerque, New Mexico 87131-0001, United States.ORCID 0000-0002-1479-3318
Sharon J Nieter BurgmayerDepartment of Chemistry, Bryn Mawr College, Bryn Mawr, Pennsylvania 19010, United States.ORCID 0000-0002-4918-0108

Funding

Spectroscopic Studies of Molybdoenzymes & ModelsR01GM057378 · NIGMS · UNIVERSITY OF NEW MEXICO · PI MARTIN L KIRK · 1998 to 2026
$6.9M
Molybdenum Pterin-Dithiolene Complexes for Model Studies of the Catalytic Site ofR15GM081848 · NIGMS · BRYN MAWR COLLEGE · PI BURGMAYER, SHARON NIETER · 2007 to 2014
$496k
NIGMS NIH HHS R01 GM057378NIGMS NIH HHS R15 GM081848
6 · The paper itself

Abstract

The molybdenum (Moco) and tungsten (Tuco) cofactors are uniquely found in pyranopterin dithiolene (PDT) molybdenum and tungsten enzymes, yet the roles of this electronically complex PDT ligand in the catalytic cycles of these enzymes has yet to be revealed. After more than a decade of effort, we have synthesized and characterized a model compound containing a reduced PDT ligand coordinated to a diamagnetic d

Indexed as

CoenzymesMolybdenumPterinsLigandsModels, MolecularMolybdenum CofactorsOxidation-ReductionCoenzymesLigandsMolybdenumMolybdenum CofactorsPterinspyranopterin

Identifiers

PMID40289353
PMCPMC12063175

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.