ArticlePakistan journal of medical sciences2025
Comparison of the efficacy of noninvasive positive pressure ventilation combined with and without budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler in the treatment of acute exacerbations of Chronic Obstructive Pulmonary Disease.
Article in Pakistan journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Mechanical ventilation, such as noninvasive positive pressure ventilation (NIPPV), is often used to relieve the symptoms of acute exacerbations of chronic obstructive pulmonary disease (AECOPD), but its treatment effect is limited. This study explored the application effect of NIPPV combined with budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler (BGF MDI) in AECOPD. Methods: The clinical records of 152 patients with AECOPD treated in the First People's Hospital of Yongkang City from March 2023 to March 2024 were retrospectively selected and grouped based on the ventilation method used: simple NIPPV treatment (n=78) and NIPPV combined with BGF MDI (n=74). The primary outcome was improvement in oxygenation; the secondary outcomes were the recovery of body function and levels of inflammatory markers. Results: After two weeks of treatment, the arterial partial pressure of carbon dioxide (PaCO2) in the combination group was significantly lower than in the NIPPV group, while the arterial partial pressure of oxygen (PaO2) and oxygenation index (OI) were significantly higher (P<0.05). The COPD Assessment Test (CAT) and St George's Respiratory Questionnaire (SGRQ) scores of the combined group were significantly lower, while the 6-minute walking test (6MWT) score was higher compared to the NIPPV group (P<0.05). The levels of C-reactive protein (CRP) and interleukin-6 (IL-6) in the combined group were significantly lower compared to the NIPPV group (P<0.05). Conclusions: NIPPV combined with BGF MDI has higher benefits than NIPPV alone for treating patients with AECOPD.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.