Evidence mapPaperPMID 40290419Full record

ArticleAmerican journal of preventive cardiology2025

Disparities in statin use in patients with ASCVD with vs without rheumatologic diseases in a large integrated healthcare system: Houston methodist CVD learning health system registry.

Eleonora Avenatti, Helene DiGregorio, Elia El Hajj, Rakesh Gullapelli, Kenneth Williams, Izza Shahid, Budhaditya Bose, Kobina Hagan, Juan C Nicolas, Shubham Lahan and 9 more

Abstract read
In one paragraph

Article in American journal of preventive cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Eleonora AvenattiDepartment of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Division of Cardiovascular Prevention, Houston Methodist Academic Institute, 6550 Fannin St Suite 1101, Houston, TX 77030, USA.
Helene DiGregorioDepartment of Internal Medicine, Houston Methodist Hospital, Houston, TX, USA.
Elia El HajjDepartment of Internal Medicine, Houston Methodist Hospital, Houston, TX, USA.
Rakesh GullapelliCenter for Health Data Science and Analytics, Houston Methodist, Houston, TX, United States.
Kenneth WilliamsDepartment of Internal Medicine, Houston Methodist Hospital, Houston, TX, USA.
Izza ShahidCenter for Health Data Science and Analytics, Houston Methodist, Houston, TX, United States.
Budhaditya BoseCenter for Health Data Science and Analytics, Houston Methodist, Houston, TX, United States.
Kobina HaganCenter for Health Data Science and Analytics, Houston Methodist, Houston, TX, United States.
Juan C NicolasCenter for Health Data Science and Analytics, Houston Methodist, Houston, TX, United States.
Shubham LahanCenter for Health Data Science and Analytics, Houston Methodist, Houston, TX, United States.
Nwabunie NwanaCenter for Health Data Science and Analytics, Houston Methodist, Houston, TX, United States.
Sara Ayaz ButtCenter for Health Data Science and Analytics, Houston Methodist, Houston, TX, United States.
Kanika MongaDepartment of Medicine, Division of Rheumatology, Houston Methodist Hospital, Houston, TX, USA.
Lily Anne Romero KaramDepartment of Medicine, Division of Rheumatology, Houston Methodist Hospital, Houston, TX, USA.
Myriam GuevaraDepartment of Medicine, Division of Rheumatology, Houston Methodist Hospital, Houston, TX, USA.
Zulqarnain JavedCenter for Health Data Science and Analytics, Houston Methodist, Houston, TX, United States.
Brittany WeberDepartment of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Sadeer Al-KindiDepartment of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Division of Cardiovascular Prevention, Houston Methodist Academic Institute, 6550 Fannin St Suite 1101, Houston, TX 77030, USA.
Khurram NasirDepartment of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Division of Cardiovascular Prevention, Houston Methodist Academic Institute, 6550 Fannin St Suite 1101, Houston, TX 77030, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The comorbid presence of Rheumatologic Diseases (RDs) and Atherosclerotic Cardiovascular Disease (ASCVD) substantially accentuates cardiovascular risk. We aimed to compare rates of secondary prevention statin utilization in patients with established ASCVD both with and without underlying comorbid RDs- and to highlight any potential gender, racial, or ethnic disparities in statin use in a contemporary US cohort. Methods: We queried the electronic medical record (EHR)-linked Houston Methodist Learning Health System Outpatient Registry containing data for approximately 1.2 million patients to identify patients with diagnosed ASCVD and RDs using ICD-10 codes. Statin prescription rates and dosage were evaluated via ATC codes. Results: Among 113,021 patients with ASCVD, 7286 (6.4 %) had comorbid RDs. The majority (71.1 %) of patients with ASCVD were prescribed statins, with discernibly lower utilization in patients with comorbid RDs compared to the non-RD population (63.2 % vs. 71.7 %, Conclusion: In this real-world study, co-morbid RDs were associated with significant lower utilization of secondary prevention statin therapy in patients with ASCVD. A multidisciplinary team approach may help to better understand key drivers of statin uptake in this clinically vulnerable population.

Indexed as

Cardio-rheumatologyCardiovascular diseaseCardiovascular riskGender disparitiesHealth equityRheumatological disordersStatins

Identifiers

PMID40290419
PMCPMC12023777

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.