Evidence map›Paper›PMID 40290438›Full record

ReviewFrontiers in pharmacology2025

The molecular determinants regulating redox signaling in diabetic endothelial cells.

Swayam Prakash Srivastava, Olivia Kopasz-Gemmen, Aaron Thurman, Barani Kumar Rajendran, M Masilamani Selvam, Sandeep Kumar, Rohit Srivastava, M Xavier Suresh, Reena Kumari, Julie E Goodwin and 1 more

Abstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. [Mechanism of silibinin in renal injury induced by periodontitis in mice].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026
    Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Swayam Prakash SrivastavaLife Sciences Institute, University of Michigan, Ann Arbor, MI, United States.
Olivia Kopasz-Gemmen *Life Sciences Institute, University of Michigan, Ann Arbor, MI, United States.
Aaron Thurman *Life Sciences Institute, University of Michigan, Ann Arbor, MI, United States.
Barani Kumar RajendranDepartment of Pathology, Yale School of Medicine, Yale University, New Haven, CT, United States.
M Masilamani SelvamDepartment of Pharmaceutical Technology, Paavai Engineering College, Namakkal, Tamil Nadu, India.
Sandeep KumarDepartment of Cellular Biology and Anatomy, Augusta University, Augusta, GA, United States.
Rohit SrivastavaLaboratory of Medical Transcriptomics, Department of Endocrinology, Nephrology Services, Hadassah Hebrew-University Medical Center, Jerusalem, Israel.
M Xavier SureshSchool of Advanced Sciences and Languages, VIT Bhopal University, Sehore, Madhya Pradesh, India.
Reena KumariDepartment of Physiology, Augusta University, Augusta, GA, United States.
Julie E GoodwinDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, United States.
Ken InokiLife Sciences Institute, University of Michigan, Ann Arbor, MI, United States.

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Endothelial glucocorticoid receptor suppresses vascular inflammationR01HL131952 · NHLBI · YALE UNIVERSITY · PI GOODWIN, JULIE · 2016 to 2025
$4.9M
NHLBI NIH HHS R01 HL131952NIDDK NIH HHS P30 DK020572
6 · The paper itself

Abstract

Oxidation and reduction are vital for keeping life through several prime mechanisms, including respiration, metabolism, and other energy supplies. Mitochondria are considered the cell's powerhouse and use nutrients to produce redox potential and generate ATP and H

Indexed as

AMPKdiabetesEndMTendothelial cellsendothelial dysfunctionsmTORC1

Identifiers

PMID40290438
PMCPMC12023289

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.