Evidence map›Paper›PMID 40290556›Full record

ReviewCureus2025

Impact of Testosterone on Male Health: A Systematic Review.

Julio G Rojas-Zambrano, Augusto Rojas-Zambrano, Andres F Rojas-Zambrano

Abstract readReview
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Testosterone and Bone Health in Men.Current osteoporosis reports · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Julio G Rojas-ZambranoGynecology, Dr. Regeneración, Guayaquil, ECU.
Augusto Rojas-ZambranoGeneral Medicine, Dr. Regeneración, Guayaquil, ECU.
Andres F Rojas-ZambranoMedicine, Dr. Regeneración, Guayaquil, ECU.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development and maintenance of muscular mass, bone density, and general physical strength depend heavily on testosterone, a hormone that plays a complicated and significant role in men's physiology. Beyond these physical advantages, testosterone plays a crucial role in male reproductive health by affecting spermatogenesis (the generation of sperm), libido, and erectile function. It has an effect on many body systems, underscoring its importance for men's physical health and fertility. The goal of this study is to learn more about the critical and varied roles that testosterone plays in healthy men's physiological functioning. The following MeSH terms were used in a PubMed search that covered the years 1998 to the present: (((testosterone) OR (androgens)) OR (testosterone insufficiency)) AND (healthy men)) AND (testosterone replacement). Descriptive, observational, and experimental studies including healthy men-more especially, those assessing the effects of testosterone therapy-were required for inclusion. Testosterone supplements can have a good impact on a number of important aspects of men's health, such as vascular endothelial function, mood (particularly in lowering depression), muscle strength, bone health, and sexual function. Small sample sizes and a dearth of studies, however, limit these findings, highlighting the need for more investigation to completely comprehend the wider impacts of testosterone on men's health. Testosterone therapy has modest advantages, especially for men who have hypogonadism symptoms and low testosterone levels. These advantages include better vascular function, mood, muscle strength, bone density, and sexual health in healthy men. Considering the prospective benefits of testosterone therapy, more investigation and clinical testing are necessary to completely comprehend its effects and improve therapeutic modalities. Further research will better define the function of testosterone in both healthy and deficient men, which will eventually result in more accurate and successful treatment plans.

Indexed as

bone strengthmale hormonemenmoodmuscle masstestosterone

Identifiers

PMID40290556
PMCPMC12023631

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.