Evidence map›Paper›PMID 40290757›Full record

ReviewTherapeutic advances in hematology2025

Molecular genetics profiling of core-binding factor acute myeloid leukemia in pediatrics.

Zhilin Hu, Xue Tang, Fen Chen, Tonghui Li, Yi Liu, Guichi Zhou, Shilin Liu, Ying Wang, Sixi Liu, Huirong Mai and 1 more

Abstract readReview
In one paragraph

Review in Therapeutic advances in hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Using genomics to refine pediatric AML risk stratification.Hematology. American Society of Hematology. Education Program · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhilin HuShantou University Medical College, Shantou, Guangdong, China.ORCID https://orcid.org/0009-0001-2187-9398
Xue TangDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
Fen ChenDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
Tonghui LiDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
Yi LiuDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
Guichi ZhouDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
Shilin LiuDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
Ying WangDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
Sixi LiuDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.ORCID https://orcid.org/0000-0003-1674-2685
Huirong MaiDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
Lulu WangDepartment of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, Guangdong 518026, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Core-binding factor acute myeloid leukemia (CBF-AML) is a subtype of AML characterized by specific genetic rearrangements, including t(8;21) and inv(16), which are associated with a relatively favorable prognosis with relapse rates around 30%. The mutational profiling of CBF-AML is highly heterogeneous in pediatrics, with mutations in the tyrosine kinase pathway (including

Indexed as

acute myeloid leukemiacore-binding factorgeneticsmutationpediatrics

Identifiers

PMID40290757
PMCPMC12033452

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.