ArticleMolecular therapy. Methods & clinical development2025
Bystander editing by adenine base editors impairs vision restoration in a mouse model of Leber congenital amaurosis.
Article in Molecular therapy. Methods & clinical development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Engineered ADARs enable precision A-to-G base editing of DNA.Nature biotechnology · 2026Article
- ABE9 fused to SpRY Cas9 nickase enables precise generation of bystander free mouse models.Scientific reports · 2026Article
- Recent preclinical and clinical advances in gene therapy for hereditary hearing loss.Molecules and cells · 2025Review
- Precise Correction of theResearch (Washington, D.C.) · 2025Article
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Authors and funding
11 authors.
Funding
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Abstract
Base editors (BEs) have emerged as a powerful tool for gene correction with high activity. However, bystander base editing, a byproduct of BEs, presents challenges for precise editing. Here, we investigated the effects of bystander edits on phenotypic restoration in the context of Leber congenital amaurosis (LCA), a hereditary retinal disorder, as a therapeutic model. We observed that in
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