ArticleFrontiers in medicine2025
Diagnostic value of serum TGF-β1 and CysC in type 2 diabetic kidney disease: a cross-sectional study.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Cystatin C Mirrors Fibrosis Burden in Metabolic Syndrome: Insights from the Metabolic Dysfunction-Associated Fibrosis-5 Score.Metabolites · 2026Article
- Potential of circulating miR-29a and miR-142-5p as biomarkers for diabetic nephropathy: a cross-sectional study.Frontiers in medicine · 2026Article
- A non-invasive predictive model for identifying non-diabetic kidney disease in type 2 diabetes mellitus: development and multicenter validation.American journal of clinical and experimental urology · 2026Article
- Machine learning-based prediction of tubulointerstitial lesions in diabetic kidney disease: a multicenter validation study.Renal failure · 2025Article
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9 authors.
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Abstract
Background: Diabetic kidney disease (DKD) is one of the common microvascular complications of diabetes. The exploration of serum biomarkers holds promise for improving the efficiency and accuracy of early DKD diagnosis. This study aims to investigate the diagnostic value of transforming growth factor-β1 (TGF-β1) and cystatin C (CysC) in DKD patients. Methods: A total of 126 patients with type 2 diabetes mellitus (T2DM) diagnosed at Dongzhimen Hospital, Beijing University of Chinese Medicine, between May 2021 and March 2023 were enrolled. Patients were categorized based on proteinuria levels and estimated glomerular filtration rate (eGFR). Correlation analyses were conducted to examine the relationships between serum TGF-β1, CysC, and clinical parameters. Logistic regression was applied to identify correlation factors for DKD and renal function impairment in T2DM patients. Furthermore, receiver operating characteristic (ROC) curve analysis was performed to assess diagnostic efficacy. Results: Significant differences in TGF-β1 and CysC levels were observed across groups with varying proteinuria levels. CysC was positively correlated with TGF-β1 ( Conclusion: CysC and TGF-β1 can serve as potential biomarkers for assessing renal impairment and proteinuria in T2DM patients. Their combined evaluation demonstrates diagnostic value and clinical application potential.
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