Evidence map›Paper›PMID 40291376›Full record

ArticleMolecular therapy. Nucleic acids2025

An inflammation-associated lncRNA induces neuronal damage via mitochondrial dysfunction.

Ane Olazagoitia-Garmendia, Henar Rojas-Márquez, Tim Trobisch, Cristina Moreno-Castro, Ariadne Rodriguez Etxebarria, Jon Mentxaka, Ajai Tripathi, Bibo Yang, Itziar Martin Ruiz, Juan Anguita and 7 more

Abstract read
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In one paragraph

Article in Molecular therapy. Nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ane Olazagoitia-GarmendiaDepartment of Biochemistry and Molecular Biology, University of Basque Country UPV/EHU, 48940 Leioa, Spain.
Henar Rojas-MárquezBiobizkaia Health Research Institute, Cruces-Barakaldo 48903, Spain.
Tim TrobischDepartment of Neurology, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Cristina Moreno-CastroULB Center for Diabetes Research, Université Libre de Bruxelles (ULB), 1050 Bruxelles, Belgium.
Ariadne Rodriguez EtxebarriaDepartment of Biochemistry and Molecular Biology, University of Basque Country UPV/EHU, 48940 Leioa, Spain.
Jon MentxakaDepartment of Biochemistry and Molecular Biology, University of Basque Country UPV/EHU, 48940 Leioa, Spain.
Ajai TripathiDepartment of Neuroscience, Lerner Research Institute, Cleveland Clinic, Cleveland OH 44106, US.
Bibo YangDepartment of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.
Itziar Martin RuizCIC bioGUNE-BRTA, 48160 Derio, Spain.
Juan AnguitaCIC bioGUNE-BRTA, 48160 Derio, Spain.
J Javier MeanaBiobizkaia Health Research Institute, Cruces-Barakaldo 48903, Spain.
Yiliang DingDepartment of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.
Ranjan DuttaDepartment of Neuroscience, Lerner Research Institute, Cleveland Clinic, Cleveland OH 44106, US.
Lucas SchirmerDepartment of Neurology, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Mariana Igoillo-EsteveULB Center for Diabetes Research, Université Libre de Bruxelles (ULB), 1050 Bruxelles, Belgium.
Izortze SantinDepartment of Biochemistry and Molecular Biology, University of Basque Country UPV/EHU, 48940 Leioa, Spain.
Ainara Castellanos-RubioBiobizkaia Health Research Institute, Cruces-Barakaldo 48903, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune disease-associated non-coding SNPs, which often locate in tissue-specific regulatory elements, are emerging as key factors in gene regulation. Among these elements, long non-coding RNAs (lncRNAs) participate in many cellular processes, and their characteristics make these molecules appealing therapeutic targets. In this study, we have studied lncRNA

Indexed as

braincell-specificitylncRNAmetabolismmitochondriaMT: non-coding RNAsmultiple sclerosisneuroinflammationRNA modificationSNP

Identifiers

PMID40291376
PMCPMC12023888

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.