Evidence map›Paper›PMID 40291381›Full record

ArticlePain reports2025

A genome-wide association study identifies novel genetic variants associated with neck or shoulder pain in the UK biobank (N = 430,193).

Yiwen Tao, Qi Pan, Tengda Cai, Zen Huat Lu, Mainul Haque, Tania Dottorini, Lesley A Colvin, Blair H Smith, Weihua Meng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yiwen TaoNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, China.ORCID https://orcid.org/0009-0000-0102-4205
Qi PanNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, China.ORCID https://orcid.org/0000-0003-0135-9122
Tengda CaiNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, China.ORCID https://orcid.org/0000-0003-1617-506X
Zen Huat LuPAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Bandar Seri Begawan, Brunei Darussalam.ORCID https://orcid.org/0000-0002-9408-0579
Mainul HaqueSchool of Mathematical Sciences, University of Nottingham Ningbo China, Ningbo, China.ORCID https://orcid.org/0000-0003-1836-8076
Tania DottoriniSchool of Veterinary Medicine and Science, University of Nottingham, Nottingham, United Kingdom.ORCID https://orcid.org/0000-0001-7733-906X
Lesley A ColvinDivision of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom.ORCID https://orcid.org/0000-0002-1563-8600
Blair H SmithDivision of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom.ORCID https://orcid.org/0000-0002-5362-9430
Weihua MengNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, China.ORCID https://orcid.org/0000-0001-5388-8494

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Neck and shoulder pain are prevalent musculoskeletal disorders that significantly affect the quality of life for a substantial portion of the global population. Studies have shown that women are more susceptible than men. Objective: This study aims to discover genetic variants associated with neck or shoulder pain through a genome-wide association study (GWAS), using data from 430,193 participants in the UK Biobank. Methods: A genome-wide association study was performed adjusting for age, sex, BMI, and 8 population principal components. Significant and independent genetic variants were replicated by FinnGen. Results: The primary GWAS revealed 5 significant genetic loci (including 2 novel) associated with neck or shoulder pain, with the most significant single nucleotide polymorphism (SNP) being rs9889282 ( Conclusion: In summary, this study has identified novel genetic variants for neck or shoulder pain. Sex-stratified GWAS also suggested that sex played a role in the occurrence of the phenotype.

Indexed as

Genetic correlationsGenome-wide association studyGenomicsNeck or shoulder painPhenome-wide association analysisUK Biobank

Identifiers

PMID40291381
PMCPMC12026381

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.